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Volume 7, Issue 2 (May 2019)                   Res Mol Med (RMM) 2019, 7(2): 0-0 | Back to browse issues page

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Taghadosi C, Kojouri G, Ahadi A, Hashemi Bahremani M. Bovine Leukaemia Virus onco-protein Tax antigen identification in human lymphomas tissue. Res Mol Med (RMM). 2019; 7 (2)
URL: http://rmm.mazums.ac.ir/article-1-311-en.html
Abstract:   (116 Views)
Background: Bovine leukaemia virus (BLV) is the primary cause of enzootic bovine leukaemia which belongs to the HTLV/BLV group of oncogenic retroviruses including Human T-cell leukaemia virus types 1, 2, and 3 and simian T-lymphotropic virus. Due to daily consumption of milk, meat and other dairy by-products, a possible role in appearing human cancers can be assumed for BLV. Materials and Methods: In the present study, formalin-fixed, paraffin-embedded and fresh human lymphomas tissues were used for detecting the BLV Tax genome and BLV Tax expression using nested-PCR and RT-nested-PCR.
Results: Nested-PCR evaluation showed that 9 of 41 samples contained Tax region of BLV genome, which eight samples belonged to high grade diffuse large cell lymphoma (B-cell type). Also, the results of RT-nested-PCR showed the BLV Tax expression in 2 of 5 samples that both were high grade diffuse large cell lymphoma (B-cell type).
Conclusion: These findings can explain the possible relation between BLV infection and the occurrence of some types of human lymphomas for the first time.
 
     
Type of Study: Research | Subject: Microbiology
Received: 2019/05/29

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