Volume 7, Issue 2 (May 2019)
Res Mol Med (RMM) 2019, 7(2): 25-32 |
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Taghadosi C, Kojouri G, Ahadi A, Hashemi Bahremani M, Kojouri A. Bovine Leukaemia Virus Tax Antigen Identification in Human Lymphoma Tissue: Possibility of onco-protein Gene Ttransmission. Res Mol Med (RMM) 2019; 7 (2) :25-32
URL: http://rmm.mazums.ac.ir/article-1-311-en.html
URL: http://rmm.mazums.ac.ir/article-1-311-en.html
Camellia Taghadosi1 
, Gholamali Kojouri 2, Alimohammad Ahadi3 , Mohammad Hashemi Bahremani4 , Abdolnabi Kojouri5
, Gholamali Kojouri 2, Alimohammad Ahadi3 , Mohammad Hashemi Bahremani4 , Abdolnabi Kojouri5
1- Graduated student, Faculty of Veterinary Medicine, Shahrekord university, Shahrekord, Iran.
2- Professor, Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahrekord university ,drgholam_alikojouri@yahoo.com
3- Assistant Professor, Department of Genetic, Faculty of Basic Sciences, Shahrekord University, Shahrekord, Iran.
4- Associate Professor, Laboratory of Pathology, Emam Hosein Hospital, Tehran, Iran.
5- Faculty of Medicine, International Campus of Shahid Sadoughi Medical University, Yazd, Iran
2- Professor, Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahrekord university ,
3- Assistant Professor, Department of Genetic, Faculty of Basic Sciences, Shahrekord University, Shahrekord, Iran.
4- Associate Professor, Laboratory of Pathology, Emam Hosein Hospital, Tehran, Iran.
5- Faculty of Medicine, International Campus of Shahid Sadoughi Medical University, Yazd, Iran
Abstract: (6192 Views)
Background: Bovine leukaemia virus (BLV) is the cause of enzootic bovine leukaemia which belongs to retroviruses including Human T-cell leukaemia virus and simian T-lymphotropic virus. Due to this familiarity, the possibility of virus (BLV) transfer from animal production to humans may exist.
Materials and methods: In the present study, formalin-fixed, paraffin-embedded and fresh human lymphomas tissues were used for detecting the BLV Tax genome and BLV Tax expression using nested-PCR and RT-nested-PCR.
Results: Nested-PCR evaluation showed that 9 of 41 samples contained Tax region of BLV genome, of which eight samples belonged to high grade diffuse large cell lymphoma (B-cell type). Also, the results of RT-nested-PCR showed the BLV Tax expression in 2 of 5 high grade diffuse large cell lymphoma (B-cell type) samples.
Conclusion: These findings explain the possible relation between BLV infection and the occurrence of some types of human lymphomas for the first time.
Materials and methods: In the present study, formalin-fixed, paraffin-embedded and fresh human lymphomas tissues were used for detecting the BLV Tax genome and BLV Tax expression using nested-PCR and RT-nested-PCR.
Results: Nested-PCR evaluation showed that 9 of 41 samples contained Tax region of BLV genome, of which eight samples belonged to high grade diffuse large cell lymphoma (B-cell type). Also, the results of RT-nested-PCR showed the BLV Tax expression in 2 of 5 high grade diffuse large cell lymphoma (B-cell type) samples.
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