دوره 7، شماره 2 - ( 2-1398 )
جلد 7 شماره 2 صفحات 32-25 |
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Taghadosi C, Kojouri G, Ahadi A, Hashemi Bahremani M, Kojouri A. Bovine Leukaemia Virus Tax Antigen Identification in Human Lymphoma Tissue: Possibility of onco-protein Gene Ttransmission. Res Mol Med (RMM) 2019; 7 (2) :25-32
URL: http://rmm.mazums.ac.ir/article-1-311-fa.html
URL: http://rmm.mazums.ac.ir/article-1-311-fa.html
Bovine Leukaemia Virus Tax Antigen Identification in Human Lymphoma Tissue: Possibility of onco-protein Gene Ttransmission. Research in Molecular Medicine. 1398; 7 (2) :25-32
چکیده: (4885 مشاهده)
Background: Bovine leukaemia virus (BLV) is the cause of enzootic bovine leukaemia which belongs to retroviruses including Human T-cell leukaemia virus and simian T-lymphotropic virus. Due to this familiarity, the possibility of virus (BLV) transfer from animal production to humans may exist.
Materials and methods: In the present study, formalin-fixed, paraffin-embedded and fresh human lymphomas tissues were used for detecting the BLV Tax genome and BLV Tax expression using nested-PCR and RT-nested-PCR.
Results: Nested-PCR evaluation showed that 9 of 41 samples contained Tax region of BLV genome, of which eight samples belonged to high grade diffuse large cell lymphoma (B-cell type). Also, the results of RT-nested-PCR showed the BLV Tax expression in 2 of 5 high grade diffuse large cell lymphoma (B-cell type) samples.
Conclusion: These findings explain the possible relation between BLV infection and the occurrence of some types of human lymphomas for the first time.
Materials and methods: In the present study, formalin-fixed, paraffin-embedded and fresh human lymphomas tissues were used for detecting the BLV Tax genome and BLV Tax expression using nested-PCR and RT-nested-PCR.
Results: Nested-PCR evaluation showed that 9 of 41 samples contained Tax region of BLV genome, of which eight samples belonged to high grade diffuse large cell lymphoma (B-cell type). Also, the results of RT-nested-PCR showed the BLV Tax expression in 2 of 5 high grade diffuse large cell lymphoma (B-cell type) samples.
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