Volume 14, Issue 3 (Aug 2026)
Res Mol Med (RMM) 2026, 14(3): 0-0 |
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Dahash AL-Shiblawi A A, Hosseini F S, Mousavi Kisari F S, Eskandari Ghadi S, Khonakdar A, Musavi H. Uric Acid-to-HDL Cholesterol Ratio Is Not Associated with Coronary Artery Disease in Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Comparative Study. Res Mol Med (RMM) 2026; 14 (3)
URL: http://rmm.mazums.ac.ir/article-1-656-en.html
URL: http://rmm.mazums.ac.ir/article-1-656-en.html
Abbas Abdulhussein Dahash AL-Shiblawi1 
, Fatemeh Sadat Hosseini1 , Farimah sadat Mousavi Kisari2 , Sahar Eskandari Ghadi2 , Abbas Khonakdar3 , Hadis Musavi4
, Fatemeh Sadat Hosseini1 , Farimah sadat Mousavi Kisari2 , Sahar Eskandari Ghadi2 , Abbas Khonakdar3 , Hadis Musavi4
1- Department of Clinical Biochemistry and Genetics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
2- Assistant Professor, Department of Cardiology, Faculty of Medicine, Cardiovascular Research Center, Mazandaran University of Medical Sciences, Sari, Iran
3- Department of Clinical Biochemistry and Genetics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. & Immunogenetics Research Center, Mazandaran University of Medical Sciences, Sari, Iran ,khonakdarab@gmail.com
4- Department of Clinical Biochemistry and Genetics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. & Thalassemia Research Center, Hemoglobinophaty Institute, Mazandaran University of Medical Sciences, Sari, Iran
2- Assistant Professor, Department of Cardiology, Faculty of Medicine, Cardiovascular Research Center, Mazandaran University of Medical Sciences, Sari, Iran
3- Department of Clinical Biochemistry and Genetics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. & Immunogenetics Research Center, Mazandaran University of Medical Sciences, Sari, Iran ,
4- Department of Clinical Biochemistry and Genetics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. & Thalassemia Research Center, Hemoglobinophaty Institute, Mazandaran University of Medical Sciences, Sari, Iran
Abstract: (24 Views)
Background: The uric acid-to-high-density lipoprotein cholesterol ratio (UHR) has recently emerged as a potential cardiometabolic biomarker. This study evaluated the association between UHR and coronary artery disease (CAD), glycemic control, and lipid-related parameters in patients with type 2 diabetes mellitus (T2DM).
Methods: In this cross-sectional comparative study, 120 patients with T2DM were enrolled and categorized into those with angiographically documented CAD (DM_CD, n = 60) and those without CAD (DM, n = 60). Fasting blood glucose levels, HbA1c levels, lipid profile, serum uric acid levels, creatinine levels, complete blood count parameters, inflammatory indices, and the triglyceride-glucose (TyG) index were measured. UHR was calculated as serum uric acid divided by high-density lipoprotein cholesterol (HDL-C). Group comparisons, correlation analyses, and multivariable logistic regression were performed.
Results: UHR did not differ significantly between patients with and without CAD (0.139±0.060 vs. 0.126±0.045, P=0.123) and was not associated with fasting blood glucose levels, HbA1c levels, or the TyG index. Patients with CAD had significantly higher neutrophil-to-lymphocyte ratio (NLR), neutrophil count, and hematocrit, and lower lymphocyte and platelet counts (all P<0.05). In multivariable logistic regression, only NLR remained independently associated with CAD (adjusted OR=3.99, 95% CI: 1.52–10.52; P=0.005), whereas UHR, the TyG index, and HbA1c levels were not.
Conclusions: UHR was not associated with CAD or glycemic control and was not an independent predictor of CAD in patients with T2DM. These findings do not support the use of UHR for discriminating established CAD in this study population. Larger prospective studies with adjustment for potential confounding factors are warranted.
Methods: In this cross-sectional comparative study, 120 patients with T2DM were enrolled and categorized into those with angiographically documented CAD (DM_CD, n = 60) and those without CAD (DM, n = 60). Fasting blood glucose levels, HbA1c levels, lipid profile, serum uric acid levels, creatinine levels, complete blood count parameters, inflammatory indices, and the triglyceride-glucose (TyG) index were measured. UHR was calculated as serum uric acid divided by high-density lipoprotein cholesterol (HDL-C). Group comparisons, correlation analyses, and multivariable logistic regression were performed.
Results: UHR did not differ significantly between patients with and without CAD (0.139±0.060 vs. 0.126±0.045, P=0.123) and was not associated with fasting blood glucose levels, HbA1c levels, or the TyG index. Patients with CAD had significantly higher neutrophil-to-lymphocyte ratio (NLR), neutrophil count, and hematocrit, and lower lymphocyte and platelet counts (all P<0.05). In multivariable logistic regression, only NLR remained independently associated with CAD (adjusted OR=3.99, 95% CI: 1.52–10.52; P=0.005), whereas UHR, the TyG index, and HbA1c levels were not.
Conclusions: UHR was not associated with CAD or glycemic control and was not an independent predictor of CAD in patients with T2DM. These findings do not support the use of UHR for discriminating established CAD in this study population. Larger prospective studies with adjustment for potential confounding factors are warranted.
Keywords: Type 2 diabetes mellitus, Uric acid-to-HDL ratio, Coronary artery disease, Glycemic control, Lipid profile, Cardiometabolic risk..
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