en بیوشیمی Biochemistry پژوهشي Research <div style="text-align: justify;"><span style="font-size:12pt"><span new="" roman="" style="font-family:" times=""><strong>Background:</strong> The uric acid-to-high-density lipoprotein cholesterol ratio (UHR) has recently emerged as a potential cardiometabolic biomarker. This study evaluated the association between UHR and coronary artery disease (CAD), glycemic control, and lipid-related parameters in patients with type 2 diabetes mellitus (T2DM).</span></span><br> <span style="font-size:12pt"><span new="" roman="" style="font-family:" times=""><strong>Methods:</strong> In this cross-sectional comparative study, 120 patients with T2DM were enrolled and categorized into those with angiographically documented CAD (DM_CD, n = 60) and those without CAD (DM, n = 60). Fasting blood glucose levels, HbA1c levels, lipid profile, serum uric acid levels, creatinine levels, complete blood count parameters, inflammatory indices, and the triglyceride-glucose (TyG) index were measured. UHR was calculated as serum uric acid divided by high-density lipoprotein cholesterol (HDL-C). Group comparisons, correlation analyses, and multivariable logistic regression were performed.</span></span><br> <span style="font-size:12pt"><span new="" roman="" style="font-family:" times=""><strong>Results:</strong> UHR did not differ significantly between patients with and without CAD (0.139&plusmn;0.060 vs. 0.126&plusmn;0.045, P=0.123) and was not associated with fasting blood glucose levels, HbA1c levels, or the TyG index. Patients with CAD had significantly higher neutrophil-to-lymphocyte ratio (NLR), neutrophil count, and hematocrit, and lower lymphocyte and platelet counts (all P<0.05). In multivariable logistic regression, only NLR remained independently associated with CAD (adjusted OR=3.99, 95% CI: 1.52&ndash;10.52; P=0.005), whereas UHR, the TyG index, and HbA1c levels were not.</span></span><br> <span style="font-size:12pt"><span new="" roman="" style="font-family:" times=""><strong>Conclusions:</strong> UHR was not associated with CAD or glycemic control and was not an independent predictor of CAD in patients with T2DM. These findings do not support the use of UHR for discriminating established CAD in this study population. Larger prospective studies with adjustment for potential confounding factors are warranted.</span></span></div> Type 2 diabetes mellitus, Uric acid-to-HDL ratio, Coronary artery disease, Glycemic control, Lipid profile, Cardiometabolic risk.. 0 0 http://rmm.mazums.ac.ir/browse.php?a_code=A-10-256-2&slc_lang=en&sid=1 Abbas Abdulhussein Dahash AL-Shiblawi abbas.96abid@gmail.com 100319475328460013817 100319475328460013817 No Department of Clinical Biochemistry and Genetics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Fatemeh Sadat Hosseini malakekavir4479@gmail.com 100319475328460013818 100319475328460013818 No Department of Clinical Biochemistry and Genetics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Farimah sadat Mousavi Kisari Sf.musavi.k@gmail.com 100319475328460013819 100319475328460013819 No Assistant Professor, Department of Cardiology, Faculty of Medicine, Cardiovascular Research Center, Mazandaran University of Medical Sciences, Sari, Iran Sahar Eskandari Ghadi s.eskandari7988@gmail.com 100319475328460013820 100319475328460013820 No Assistant Professor, Department of Cardiology, Faculty of Medicine, Cardiovascular Research Center, Mazandaran University of Medical Sciences, Sari, Iran Abbas Khonakdar khonakdarab@gmail.com 100319475328460013821 100319475328460013821 Yes Department of Clinical Biochemistry and Genetics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Hadis Musavi msc.musavi66@gmail.com 100319475328460013822 100319475328460013822 No Department of Clinical Biochemistry and Genetics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.