Volume 13, Issue 3 (Aug 2025)                   Res Mol Med (RMM) 2025, 13(3): 131-142 | Back to browse issues page

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Naderi Alizadeh M, Rahimlou M E, Rahimlou E, Vahedian V, Gharibi M, Soltani N et al . Apatinib as a Potential Therapeutic Agent in Breast Cancer Treatment With a Focus on Clinical Trials: A State-of-the-art Study. Res Mol Med (RMM) 2025; 13 (3) :131-142
URL: http://rmm.mazums.ac.ir/article-1-628-en.html
Apatinib as a Potential Therapeutic Agent in Breast Cancer Treatment With a Focus on Clinical Trials: A State-of-the-art Study
Mohammad Naderi Alizadeh1 , Mohammad Ehsan Rahimlou2 , Elham Rahimlou2 , Vahid Vahedian3 , Mahdi Gharibi4 , Nahal Soltani2 , Nazila Fathi Maroufi5
1- Functional Neurosurgey Research Center, Shohada Tajrish Comprehensive Neurosurgical Center of Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2- Department of Medical Laboratory Sciences, MAR.C., Islamic Azad University, Marand, Iran.
3- Division of Hematology and Cellular Therapy/LIM-31, Department of Internal Medicine, Faculty of Medicine, Clinical Hospital, University of São Paulo, São Paulo, Brazil. & Comprehensive Center for Translational and Precision Oncology, São Paulo State Cancer Institute (ICESP), São Paulo, Brazil. & Institute of Education and Research, Hospital São Luiz, São Paulo, Brazil.
4- Department of Pharmacy, Faculty of Pharmacy, University of Ankara, Ankara, Turkey.
5- Department of Pharmacy, Faculty of Pharmacy, University of Ankara, Ankara, Turkey. , n.fathi6788@gmail.com
Abstract:   (214 Views)

Breast cancer is the most common cancer in females. The treatment of this cancer is one of the challenges facing the world’s health system. Metastasis and cancer cell invasion are the reasons for the difficulty in treating this cancer. Also, the formation of new blood vessels, or angiogenesis, facilitates metastasis in cancer patients. Therefore, researchers are seeking new therapeutic drugs. One of the important factors in the processes of angiogenesis and metastasis is vascular endothelial growth factor and its receptor. Agents that can inhibit this molecule and its receptor will have helpful therapeutic potential for treating breast cancer. Apatinib is a drug that has drawn the attention of cancer researchers in the last decade, and many studies have been conducted on its effectiveness in cancer treatment, especially breast cancer. In this review article, we aimed to summarize the therapeutic potential of apatinib in vivo and animal models, with a focus on clinical trials.

Keywords: Apatinib, Breast cancer, Clinical trials, Metastasis
Full-Text [PDF 2987 kb]   (48 Downloads)    
Type of Study: review | Subject: Molecular biology
Published: 2026/08/19
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