Breast cancer is the most important cancer in females. The treatment of this cancer is one of the challenges facing the world health system. Metastasis and invasion of cancer cells are the basis of the difficulty of treatment in this cancer. On the other hand, the formation of new vessels or angiogenesis facilitates metastasis in cancer patients. Therefore, researchers are trying to find new therapeutic drugs. One of the important factors in the processes of angiogenesis and metastasis is   vascular endothelial growth factor (VEGF) and its receptor (VEGFR). Agents that can inhibit this molecule and its receptor will have helpful therapeutic potential for treating breast cancer. Apatinib is a drug that has attracted the attention of cancer researchers in the last decade, and many studies have been conducted on the effectiveness of this drug in the field of cancer treatment especially breast cancer. In this review article, we aimed to review the therapeutic potential of Apatinib in-vivo studies, animal models, with a focus on clinical trials.