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Rahimlou M E, Rahimlou E, Shakibfar F, Fathi Maroufi N. Potential of SARS-CoV-2 in Cancer Development: A Hypothetical and Mechanistic View. Res Mol Med (RMM) 2024; 12 (2)
URL: http://rmm.mazums.ac.ir/article-1-582-en.html

The COVID-19 pandemic caused by the SARS-CoV-2 virus can lead to long-term health effects, such as possible oncogenic properties. The evidence shows that SARS-CoV-2 may affect cellular pathways involved in cancer development, such as chronic inflammation, immune evasion, and genomic instability. This review study explores the hypothetical mechanisms by which SARS-CoV-2 contributes to oncogenesis, including persistent viral infection, dysregulation of tumor suppressor genes (e.g. p53), activation of pro-oncogenic signaling (e.g. NF-κB, JAK/STAT), and induction of long-term oxidative stress. While the evidence of the link between SARS-CoV-2 and cancer remains limited, like other oncogenic viruses, including HPV and EBV, further investigation is needed. Further epidemiological and molecular studies are needed to validate these hypotheses and assess the potential oncogenic impact of SARS-CoV-2.