دوره 12، شماره 2 - ( 2-1403 )
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Fathi Maroufi N, Rahimlou M E, Rahimlou E, Shakibfar F. Potential of SARS-CoV-2 in Cancer Development: a Hypothetical and Mechanistic View. Res Mol Med (RMM) 2024; 12 (2)
URL: http://rmm.mazums.ac.ir/article-1-582-fa.html
URL: http://rmm.mazums.ac.ir/article-1-582-fa.html
Potential of SARS-CoV-2 in Cancer Development: a Hypothetical and Mechanistic View. Research in Molecular Medicine. 1403; 12 (2)
چکیده: (278 مشاهده)
In late December 2019, cases of unexplained pneumonia in China, Wuhan were reported (1). On January 21, 2020, the World Health Organization (WHO) provisionally designated the new coronavirus as coronavirus-2019 (COVID-19). Subsequently, the virus was named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 is an enveloped, non-segmented virus containing a single-stranded, positive-sense RNA genome, belonging to the Coronaviridae family (2). Due to the pathogenesis of SARS-CoV-2 and the inflammatory response it triggers in the body, the virus may cause secondary complications that manifest in the long term. One of the potential long-term complications of SARS-CoV-2 could be carcinogenesis. Supporting this hypothesis, it has been estimated that about 15% of all human cancers worldwide are associated with viral infections. Both DNA and RNA viruses are capable of developing cancer in humans. In this regard, Epstein-Barr virus (3), human herpesvirus 8 (4), hepatitis B virus (5), and (6) are the four DNA viruses whose role in carcinogenesis has been indicated. Among the RNA viruses, Human T lymphotropic virus type 1 (7) and hepatitis C (8) viruses are known to contribute to human cancers. Given the importance of the issue and the worldwide distribution of SARS-CoV-2, the carcinogenic potential of this virus should be investigated. In this hypothetical article, we reviewed the possible mechanisms by which SARS-CoV-2 could be involved in cancer development.
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