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Volume 2, Number 3 (Jul 2014)                   Res Mol Med (RMM) 2014, 2(3): 36-40 | Back to browse issues page




DOI: 10.18869/acadpub.rmm.2.3.36

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Nasiri M, Roostaei A, Ehsanian Z. Association of Methylenetetrahydrofolate Reductase (MTHFR) Gene C677T and A1298C Polymorphisms with Myocardial Infarction From North of Fars Province. Res Mol Med (RMM). 2014; 2 (3) :36-40
URL: http://rmm.mazums.ac.ir/article-1-95-en.html

Abstract:   (2163 Views)

Background: The association between Methylene tetrahydrofolate reductase polymorphism and Coronary Artery diseases risk has been both confirmed and refuted in a number of published studies. The aim of this study was to investigate whether genetic polymorphisms of MTHFR (C677T, A1298C) contributed to the development of myocardial infarction (MI).

Materials and Methods: The present case-control study consisted of 54 patients with a history of MI and 54 gender-matched normal controls. The SNPs genotypes were determined using polymerase chain reaction followed by restriction fragment length polymorphism method.

Results: No significant association of the MTHFR A1298C with the risk of MI was observed. However, the allele frequencies of C677T SNP differed significantly among patients and controls (0.83 vs. 0.30). A strong positive relationship between the TT genotype and the risk of MI supported with a significant p-value < 0.001 (OR= 11.87, 95% CI: 4.7- 29.9, p < 0.001).

Conclusions: The results of the present study show the importance of C677T SNP as a potential biomarker for screening susceptible cases to MI.

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Type of Study: Research | Subject: Immunology
Received: 2014/08/31 | Accepted: 2014/08/31 | Published: 2014/08/31

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