Volume 14, Issue 1 (Special Issue: Leishmania 2026)
Res Mol Med (RMM) 2026, 14(1): 51-56 |
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Ziaei Hezarjaribi H, Fakhar M, Fallahi Lima A M, Tabaripour R, Hatamipour H, Mesgarian F. Atypical Cutaneous Leishmaniasis with Negative Direct Smear: Two Case Reports Confirmed by Molecular Diagnosis. Res Mol Med (RMM) 2026; 14 (1) :51-56
URL: http://rmm.mazums.ac.ir/article-1-620-en.html
URL: http://rmm.mazums.ac.ir/article-1-620-en.html
Hajar Ziaei Hezarjaribi1 
, Mahdi Fakhar2 , Amir Mohammad Fallahi Lima3 , Rabeeh Tabaripour4 , Hedieh Hatamipour5 , Fatemeh Mesgarian6
, Mahdi Fakhar2 , Amir Mohammad Fallahi Lima3 , Rabeeh Tabaripour4 , Hedieh Hatamipour5 , Fatemeh Mesgarian6
1- Toxoplasmosis Research Center, Communicable Diseases Institute, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
2- Gastroenterology and Hepatology Diseases Research Center, Shahid Beheshti Hospital, Qom University of Medical Sciences, Qom, Iran. & Iranian National Registry Center for Lophomoniasis and Toxoplasmosis, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran. ,mahdifakhar53@gmail.com
3- Mazandaran University of Medical Sciences, Sari, Iran.
4- Toxoplasmosis Research Center, Communicable Diseases Institute, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. & Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
5- Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
6- Gonabad Health Centre, Golestan University of Medical Sciences, Gonabad, Iran.
2- Gastroenterology and Hepatology Diseases Research Center, Shahid Beheshti Hospital, Qom University of Medical Sciences, Qom, Iran. & Iranian National Registry Center for Lophomoniasis and Toxoplasmosis, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran. ,
3- Mazandaran University of Medical Sciences, Sari, Iran.
4- Toxoplasmosis Research Center, Communicable Diseases Institute, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. & Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
5- Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
6- Gonabad Health Centre, Golestan University of Medical Sciences, Gonabad, Iran.
Abstract: (452 Views)
Background: Cutaneous leishmaniasis (CL) is a chronic parasitic disease caused by protozoa of the genus Leishmania, primarily transmitted to humans by bites of infected female sandflies.
Methods: This report describes two patients from Damghan with cutaneous lesions that were initially misdiagnosed as fungal infections. The lesions were evaluated using direct smear microscopy and a kDNA-based polymerase chain reaction (PCR) assay.
Results: The first patient was a 5-year-old girl with a chronic lesion on her hand. Despite a negative direct smear, kDNA-based PCR confirmed CL. The second patient was a 43-year-old man with a painful ulcerative lesion on his leg. kDNA-based PCR confirmed Leishmania major infection, and the
patient improved following treatment with Glucantime.
Conclusion: Atypical CL presents diverse clinical features, especially in children, which complicate diagnosis. Increased awareness and further research are crucial to improving outcomes and refining management strategies.
Methods: This report describes two patients from Damghan with cutaneous lesions that were initially misdiagnosed as fungal infections. The lesions were evaluated using direct smear microscopy and a kDNA-based polymerase chain reaction (PCR) assay.
Results: The first patient was a 5-year-old girl with a chronic lesion on her hand. Despite a negative direct smear, kDNA-based PCR confirmed CL. The second patient was a 43-year-old man with a painful ulcerative lesion on his leg. kDNA-based PCR confirmed Leishmania major infection, and the
patient improved following treatment with Glucantime.
Conclusion: Atypical CL presents diverse clinical features, especially in children, which complicate diagnosis. Increased awareness and further research are crucial to improving outcomes and refining management strategies.
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