Volume 14, Issue 1 (Special Issue: Leishmania 2026)
Res Mol Med (RMM) 2026, 14(1): 0-0 |
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Yazdian Robati R, Tabaripour R, Fakhar M, Ziaei Hezarjaribi H. Aptamer-Based Biosensors: Emerging Tools for Next-Generation Diagnosis of Strategic Parasitic Diseases. Res Mol Med (RMM) 2026; 14 (1)
URL: http://rmm.mazums.ac.ir/article-1-619-en.html
URL: http://rmm.mazums.ac.ir/article-1-619-en.html
1- Pharmaceutical Sciences Research Center, Institute of Herbal Medicines and Metabolic Disorders, Mazandaran University of Medical Sciences, Sari, Iran.
2- Toxoplasmosis Research Center, Communicable Diseases Institute, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. & Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
3- Toxoplasmosis Research Center, Communicable Diseases Institute, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. & Gastroenterology and Hepatology Diseases Research Center, Shahid Beheshti Hospital, Qom University of Medical Sciences, Qom, Iran. ,mahdifakhar53@gmail.com
2- Toxoplasmosis Research Center, Communicable Diseases Institute, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. & Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
3- Toxoplasmosis Research Center, Communicable Diseases Institute, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. & Gastroenterology and Hepatology Diseases Research Center, Shahid Beheshti Hospital, Qom University of Medical Sciences, Qom, Iran. ,
Abstract: (12 Views)
Parasitic diseases impose a profound global health and economic burden, particularly in resource-limited settings where rapid and accurate diagnostic infrastructure is lacking. Traditional diagnostic methods often fall short in sensitivity, specificity, and point-of-care adaptability. Aptamers—single-stranded DNA or RNA oligonucleotides selected in vitro via systematic evolution of ligands by exponential enrichment (SELEX)—have emerged as highly stable, cost-effective, and versatile biorecognition elements capable of binding diverse targets with high affinity and specificity. This review explored the mechanisms of aptamer-based biosensors (aptasensors) and their emerging applications in diagnosing strategic parasitic infections, including malaria, leishmaniasis, Chagas disease, Human African Trypanosomiasis, and giardiasis. Despite challenges, such as nuclease degradation and SELEX-related biases, aptamer-based biosensors demonstrate significant potential as reliable, sensitive, and specific tools for next-generation diagnosis and monitoring of parasitic diseases.
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