Volume 14, Issue 2 (May 2026)
Res Mol Med (RMM) 2026, 14(2): 0-0 |
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Shams N, Alami H, Shahzamani K, Amiri N. Emerging Antibiotic Resistance in Klebsiella pneumoniae Among Diabetic Patients With Urinary Tract Infections: A Regional Study from Khorramabad City, Iran. Res Mol Med (RMM) 2026; 14 (2)
URL: http://rmm.mazums.ac.ir/article-1-616-en.html
URL: http://rmm.mazums.ac.ir/article-1-616-en.html
1- Associate Professor of Microbiology, Department of Microbiology and Food , School of Veterinary Medicine, Lorestan University of Medical Sciences, Lorestan, Iran
2- PhD student in Bacteriology, Department of Microbiology and Food Hygiene , School of Veterinary Medicine, Lorestan University of Medical Sciences, Lorestan, Iran . ,hamedalami1993@gmail.com
3- Associate Professor of Medical Virology, Department of Virology, Medical School, Lorestan University of Medical Sciences, Lorestan, Iran
4- Bachelor of Microbiology, Department of Biology, Faculty of Basic Sciences, Khorramabad Azad University, Khorramabad, Iran
2- PhD student in Bacteriology, Department of Microbiology and Food Hygiene , School of Veterinary Medicine, Lorestan University of Medical Sciences, Lorestan, Iran . ,
3- Associate Professor of Medical Virology, Department of Virology, Medical School, Lorestan University of Medical Sciences, Lorestan, Iran
4- Bachelor of Microbiology, Department of Biology, Faculty of Basic Sciences, Khorramabad Azad University, Khorramabad, Iran
Abstract: (227 Views)
Background: Diabetic patients are at a heightened risk of urinary tract infections (UTIs) caused by antibiotic-resistant bacteria. This study aimed to determine the antimicrobial resistance patterns of Klebsiella pneumoniae isolated from diabetic patients with UTIs in Khorramabad City, Iran.
Methods: In this cross-sectional study (May 2020 to March 2021), 500 K. pneumoniae isolates were obtained from 3130 diabetic patients with culture-confirmed UTIs. Identification was performed using standard microbiological methods. Antimicrobial susceptibility testing against nine antibiotics was conducted via the Kirby-Bauer disk diffusion method, interpreted according to Clinical and Laboratory Standards Institute guidelines.
Results: The highest resistance rates were observed for gentamicin (66%) and ampicillin (58%). The lowest resistance was observed for cefazolin (17%), nitrofurantoin (21%), and ceftazidime (22%). Multidrug resistance was identified in 17% of isolates. The patient distribution was 57% female, 39% male, and 4% pediatric.
Conclusion: High resistance to empiric antibiotics, such as gentamicin and ampicillin, was found, underscoring the need for revised treatment guidelines and robust antimicrobial stewardship in the management of diabetic UTI in this region.
Methods: In this cross-sectional study (May 2020 to March 2021), 500 K. pneumoniae isolates were obtained from 3130 diabetic patients with culture-confirmed UTIs. Identification was performed using standard microbiological methods. Antimicrobial susceptibility testing against nine antibiotics was conducted via the Kirby-Bauer disk diffusion method, interpreted according to Clinical and Laboratory Standards Institute guidelines.
Results: The highest resistance rates were observed for gentamicin (66%) and ampicillin (58%). The lowest resistance was observed for cefazolin (17%), nitrofurantoin (21%), and ceftazidime (22%). Multidrug resistance was identified in 17% of isolates. The patient distribution was 57% female, 39% male, and 4% pediatric.
Conclusion: High resistance to empiric antibiotics, such as gentamicin and ampicillin, was found, underscoring the need for revised treatment guidelines and robust antimicrobial stewardship in the management of diabetic UTI in this region.
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