Volume 12, Issue 3 (Aug 2024)
Res Mol Med (RMM) 2024, 12(3): 67-74 |
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Parastesh M, Aria B, Torkashvand Z, Sadeghian Shahi A H. Effects of HIIT on Lipid Profile and Body Weight in Radiotherapy Rats. Res Mol Med (RMM) 2024; 12 (3) :67-74
URL: http://rmm.mazums.ac.ir/article-1-577-en.html
URL: http://rmm.mazums.ac.ir/article-1-577-en.html
1- Department of Sports Physiology, Faculty of Sports Sciences, Arak University, Arak, Iran. & Research Institute of Applied Studies of Sports Sciences, Arak University, Arak, Iran.
2- Department of Sport Sciences, Faculty of Psychology and Educational Sciences, Yazd University, Yazd, Iran. ,b.aria@yazd.ac.ir
3- Student Research Committee, School of Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
4- School of Paramedical Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
2- Department of Sport Sciences, Faculty of Psychology and Educational Sciences, Yazd University, Yazd, Iran. ,
3- Student Research Committee, School of Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
4- School of Paramedical Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Abstract: (802 Views)
Background: Dyslipidemia, marked by abnormal levels of total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides (TG), is a key risk factor for cardiovascular diseases. Radiotherapy (RT), while effective in cancer treatment, may induce adverse metabolic effects, including dyslipidemia. High-intensity interval training (HIIT) has shown potential in improving lipid metabolism. This study investigated the effects of HIIT on
lipid profiles and body weight in rats undergoing RT.
Methods: This study was an experimental, randomized controlled trial conducted over 10 weeks. Twenty-four male Wistar rats (aged 8 weeks) were randomly divided into four groups (n=6 per group): Control, HIIT, RT, and HIIT + RT. The HIIT protocol consisted of 6 sessions per week on a treadmill, including familiarization (week 1), progressive overload (weeks 2–4), and stabilization phases (weeks 5–10). RT was administered as a single 11 Gy dose using a linear accelerator. Blood samples were collected post-intervention, and lipid profiles (TG, TC, LDL, and HDL) were analyzed using enzymatic assays and a spectrophotometer. Data were analyzed by SPSS software,version 26 using one-way ANOVA and Bonferroni post-hoc test; significance was set at P<0.05.
Results: Compared to controls, RT significantly increased TC (69.3±3.1 mg/dL vs 59.5±6.3 mg/ dL, P=0.002), LDL (14.3±1.2 mg/dL vs 11.5±1 mg/dL, P=0.001), and TG (83.7±3.5 mg/dL vs 75.7±6.3 mg/dL, P=0.13) while decreasing HDL (21.7±1.4 mg/dL vs 30±3.3 mg/dL, P=0.001). HIIT significantly improved all parameters compared to RT alone: TC (52.0±2.8 mg/dL vs 69.3±3.1 mg/dL, P<0.001), LDL (9.5±1 mg/dL vs 14.3±1.2 mg/dL, P<0.001), TG (50.7±6.3 mg/dL vs 83.7±3.5 mg/dL, P<0.001), and HDL (36±3 mg/dL vs 21.7±1.4 mg/dL, P<0.001). No significant weight changes
occurred (270.4±28.7 g vs 274±18.7 g, P=0.65). HIIT may counteract RT-induced dyslipidemia.
Conclusion: These findings suggest that HIIT may counteract RT-induced dyslipidemia, highlighting its potential as a therapeutic intervention. Further studies are needed to validate these results and explore underlying mechanisms.
lipid profiles and body weight in rats undergoing RT.
Methods: This study was an experimental, randomized controlled trial conducted over 10 weeks. Twenty-four male Wistar rats (aged 8 weeks) were randomly divided into four groups (n=6 per group): Control, HIIT, RT, and HIIT + RT. The HIIT protocol consisted of 6 sessions per week on a treadmill, including familiarization (week 1), progressive overload (weeks 2–4), and stabilization phases (weeks 5–10). RT was administered as a single 11 Gy dose using a linear accelerator. Blood samples were collected post-intervention, and lipid profiles (TG, TC, LDL, and HDL) were analyzed using enzymatic assays and a spectrophotometer. Data were analyzed by SPSS software,version 26 using one-way ANOVA and Bonferroni post-hoc test; significance was set at P<0.05.
Results: Compared to controls, RT significantly increased TC (69.3±3.1 mg/dL vs 59.5±6.3 mg/ dL, P=0.002), LDL (14.3±1.2 mg/dL vs 11.5±1 mg/dL, P=0.001), and TG (83.7±3.5 mg/dL vs 75.7±6.3 mg/dL, P=0.13) while decreasing HDL (21.7±1.4 mg/dL vs 30±3.3 mg/dL, P=0.001). HIIT significantly improved all parameters compared to RT alone: TC (52.0±2.8 mg/dL vs 69.3±3.1 mg/dL, P<0.001), LDL (9.5±1 mg/dL vs 14.3±1.2 mg/dL, P<0.001), TG (50.7±6.3 mg/dL vs 83.7±3.5 mg/dL, P<0.001), and HDL (36±3 mg/dL vs 21.7±1.4 mg/dL, P<0.001). No significant weight changes
occurred (270.4±28.7 g vs 274±18.7 g, P=0.65). HIIT may counteract RT-induced dyslipidemia.
Conclusion: These findings suggest that HIIT may counteract RT-induced dyslipidemia, highlighting its potential as a therapeutic intervention. Further studies are needed to validate these results and explore underlying mechanisms.
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