Volume 12, Issue 1 (Feb 2024)
Res Mol Med (RMM) 2024, 12(1): 1-8 |
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Hosseini S A, Khajehpour F, Yazdani Z, Khajavi R, Rafiei A. Cytotoxic Effects of Methanolic and Ethanolic Extracts of Chlorella vulgaris, Scenedesmus obliquus, and Nostoc on Human Gastric Cancer Cell Line. Res Mol Med (RMM) 2024; 12 (1) :1-8
URL: http://rmm.mazums.ac.ir/article-1-570-en.html
URL: http://rmm.mazums.ac.ir/article-1-570-en.html
1- Department of Fisheries, Faculty of Fisheries and Environment, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran. , mohammadrezayazdani1373@gmail.com
2- Department of Fisheries, Faculty of Fisheries and Environment, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran.
3- Department of Immunology, Molecular and Cell Biology Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. & Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
4- Department of Immunology, Molecular and Cell Biology Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
5- Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
2- Department of Fisheries, Faculty of Fisheries and Environment, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran.
3- Department of Immunology, Molecular and Cell Biology Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. & Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
4- Department of Immunology, Molecular and Cell Biology Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
5- Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Abstract: (1054 Views)
Background: Gastric cancer is among the most frequently diagnosed and deadliest cancers worldwide. Current treatments often exhibit limited efficacy and are associated with considerable side effects.
Objective: This study aimed to evaluate the effects of methanolic and ethanolic extracts of Chlorella vulgaris (CV), Scenedesmus obliquus (SO), and Nostoc (NSC) on apoptosis in the AGS gastric cancer cell line.
Materials and Methods: The cytotoxic effects of the extracts at various concentrations were assessed using the MTT assay. Total RNA was extracted to measure BAX gene expression using quantitative real-time PCR.
Results: Extracts from all three microalgae enhanced cell death in the AGS cell line. Notably, the ethanolic extract of NSC significantly upregulated BAX gene expression.
Conclusion: The ethanolic extract of NSC shows promising anticancer potential and may serve as a candidate for future gastric cancer therapies.
Objective: This study aimed to evaluate the effects of methanolic and ethanolic extracts of Chlorella vulgaris (CV), Scenedesmus obliquus (SO), and Nostoc (NSC) on apoptosis in the AGS gastric cancer cell line.
Materials and Methods: The cytotoxic effects of the extracts at various concentrations were assessed using the MTT assay. Total RNA was extracted to measure BAX gene expression using quantitative real-time PCR.
Results: Extracts from all three microalgae enhanced cell death in the AGS cell line. Notably, the ethanolic extract of NSC significantly upregulated BAX gene expression.
Conclusion: The ethanolic extract of NSC shows promising anticancer potential and may serve as a candidate for future gastric cancer therapies.
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