Volume 1, Issue 2 (Jul 2013)                   Res Mol Med (RMM) 2013, 1(2): 3-9 | Back to browse issues page

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Moazeni M, Nabili M, Khodaveisy S, Badali H. Molecular approaches to diagnosis of invasive aspergillosis what we know and what we do not know.. Res Mol Med (RMM). 2013; 1 (2) :3-9
1- Department of Medical Mycology and Parasitology, School of Medicine/Molecular and Cell Biology Research Centre, Mazandaran University of Medical Sciences, Sari, Iran
2- Department of Medical Parasitology and Mycology, Kurdistan University of Medical Sciences, Sanandaj, Iran.Department of Medical Parasitology and Mycolog Tehran University of Medical Sciences, Tehran, Irany, ,
3- Department of Medical Mycology and Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Molecular and Cell Biology Research Centre (MCBRC), Mazandaran University of Medical Sciences, Sari, Iran.
Abstract:   (5712 Views)

Invasive aspergillosis (IA) are a major complication in immunocompromized patients where can be serious and rapidly fatal. Early diagnosis and early appropriate antifungal treatment is important in reducing mortality and morbidity. But despite many efforts to develop detection methods, the diagnosis of IA still remains challenging and current conventional methods are limited for adequate diagnosis. New rapid methods which can detect IA early in the course of disease with high sensitivity and specificity are needed since treating these infections at an early stage. Using molecular methods for Aspergillus species identification can be a cost-effective, rapid, discriminatory, and objective approach for delineating Aspergillus species in a clinical microbiology laboratory. PCR techniques for the diagnosis of IA have been studied for more than a decade and are still considered investigational, however until now PCR is not included in current EORTC/MSG diagnostic criteria.

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Type of Study: Applicable | Subject: Mycology
Received: 2013/08/30 | Accepted: 2013/10/22 | Published: 2013/10/22

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