Volume 8, Issue 3 (Aug 2020)
Res Mol Med (RMM) 2020, 8(3): 147-152 |
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Abbasinatajomrani R, Qujeq D, Hosseini V, Hajihosseini R. Evaluation of L-fucose and Sialic Acid Levels in Patients With Colorectal Cancer and Control Subject. Res Mol Med (RMM) 2020; 8 (3) :147-152
URL: http://rmm.mazums.ac.ir/article-1-377-en.html
URL: http://rmm.mazums.ac.ir/article-1-377-en.html
Evaluation of L-fucose and Sialic Acid Levels in Patients With Colorectal Cancer and Control Subject
1- Department of Biology, Payame Noor University, Tehran, Iran
2- Department of Clinical Biochemistry, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran ,dqujeq@gmail.com
3- Gut and Liver Research Center, Mazandaran University of Medical Sciences, Sari, Iran
4- Department of biochemistry, Payame Noor University, Tehran, Iran
2- Department of Clinical Biochemistry, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran ,
3- Gut and Liver Research Center, Mazandaran University of Medical Sciences, Sari, Iran
4- Department of biochemistry, Payame Noor University, Tehran, Iran
Abstract: (2692 Views)
Background: Currently, glycans, which are known as functional molecules in the biological system, are being under study as potential cancer markers. This study aimed to determine the level of serum L-fucose and sialic acid as the biomarkers in patients with colorectal cancer (CRC).
Materials and Methods: The patients with CRC (n=40, 20 men and 20 women) participated in the present study. The spectrophotometric method was used to measure the levels of L-fucose and sialic acid in the serum of the patients. SPSS (version 21) was used to analyze the obtained data. The results were expressed as mean ± SD.
Results: The mean ± SD L-fucose level in patients with CRC was 27.46 ± 4.8 ng/mL, which was more than this level in the healthy control group (18.64±3.1 ng/mL). Also, the mean ± SD serum concentration of sialic acid in patients with CRC was 2.1 ± 0.41 ng/mL, which was more than the mean ± SD sialic acid level of 1.23±0.21 ng/mL in the healthy controls.
Conclusion: Serum concentration of L-fucose and sialic acid increased significantly (P < 0.05) in patients with CRC compared with the healthy controls. We believe that determining serum L-fucose and sialic acid levels could be useful for the detection of CRC patients in the early stage.
Materials and Methods: The patients with CRC (n=40, 20 men and 20 women) participated in the present study. The spectrophotometric method was used to measure the levels of L-fucose and sialic acid in the serum of the patients. SPSS (version 21) was used to analyze the obtained data. The results were expressed as mean ± SD.
Results: The mean ± SD L-fucose level in patients with CRC was 27.46 ± 4.8 ng/mL, which was more than this level in the healthy control group (18.64±3.1 ng/mL). Also, the mean ± SD serum concentration of sialic acid in patients with CRC was 2.1 ± 0.41 ng/mL, which was more than the mean ± SD sialic acid level of 1.23±0.21 ng/mL in the healthy controls.
Conclusion: Serum concentration of L-fucose and sialic acid increased significantly (P < 0.05) in patients with CRC compared with the healthy controls. We believe that determining serum L-fucose and sialic acid levels could be useful for the detection of CRC patients in the early stage.
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