Volume 8, Issue 1 (Feb 2020)                   Res Mol Med (RMM) 2020, 8(1): 0-0 | Back to browse issues page

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Eslami M, Baghbanian M, Mirabi A M, Rafiei A. Interleukin 6 but not Interleukin 8 Might be an Indicator of Multiple Sclerosis Progression from Relapse Remitting to Secondary Progressive Status. Res Mol Med (RMM). 2020; 8 (1)
Abstract:   (599 Views)
Background and aim: Multiple Sclerosis (MS) is the most common chronic inflammatory disease of the white matter of central nervous system. Proinflammatory cytokine network such as IL-6 has a role in the initiation of destructive immune response in CNS and the progression of the disease. This study aimed to evaluate the comparative levels of IL-6 and IL-8 in MS patients and healthy controls and also assess any fluctuation in IL-6 and IL-8 levels in MS progression.
Materials and Methods: This case-control study recruited a total of 183 subjects including 103 MS patients and 80 sex- and age-matched healthy controls. MS patients included 51 RRMS, 27 PPMS, and 25 SPMS. Clinical findings were collected and serum levels of IL-6, IL-8 and 25- hydroxyl vitamin D3 (25 (OH) D3) were determined by ELISA.
Results: Serum levels of IL-6 were significantly higher in MS patients than healthy controls (23.8 ± 2.1 vs. 15.6 ± 2.7, p =0.043). MS patients with SPMS had more prominent IL-6 levels than that RRMS or PPMS (p=0.008). However, IL-8 levels did not show a significant change either in the patients compared to the controls or in the different forms of MS. MS was more prone to progressive form in men. 25 (OH) D3 levels were significantly lower in MS patients than the controls. Meanwhile, 25 (OH) D3 levels were surprisingly higher in MS patients with SPMS.  
Conclusion: Increased serum levels of IL-6 in more advanced MS status, SPMS, suggest IL-6 but not IL-8 might be a prognostic marker for the disease deterioration. In addition, the tendency for MS to progress to worse stages in affected men is an important finding that needs further clarification. 
Type of Study: Research | Subject: Immunology
Received: 2020/01/15

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