Volume 8, Issue 1 (Feb 2020)
Res Mol Med (RMM) 2020, 8(1): 37-42 |
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Nikdad S, Ghasemi H, Khiripour N, Ranjbar A. Antioxidative Effects of Nano-curcumin on Liver Mitochondria Function in Paraquat-induced Oxidative Stress. Res Mol Med (RMM) 2020; 8 (1) :37-42
URL: http://rmm.mazums.ac.ir/article-1-347-en.html
URL: http://rmm.mazums.ac.ir/article-1-347-en.html
1- Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
2- 2Department of Clinical Biochemistry, Abadan School of Medical Sciences, Abadan, Iran
3- Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
4- Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran , akranjbar2015@gmail.com
2- 2Department of Clinical Biochemistry, Abadan School of Medical Sciences, Abadan, Iran
3- Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
4- Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran , akranjbar2015@gmail.com
Abstract: (2633 Views)
Background: Paraquat (PQ), as the most widely used herbicide in agriculture, induces poisoning in humans and animals mainly through oxidative stress. This study aimed to investigate the protective effects of nano-curcumin compared with curcumin against PQ-induced mitochondrial dysfunction.
Materials and Methods: Thirty-six Wistar rats were used in this study. They were separated into 6 groups: control subjects and animals poisoned with PQ that received treatment with or without curcumin and nano-curcumin for 7 days. Liver mitochondria were isolated, and oxidative stress markers, including Total Antioxidant Capacity (TAC), Lipid Peroxidation (LPO), Catalase (CAT) and Superoxide Dismutase (SOD) activity, as well as viability and mitochondrial membrane potential, were assessed.
Results: Poisoning by PQ significantly increased the LPO levels and considerably decreased the TAC, CAT, and SOD activity compared with the control subjects (P<0.05). PQ-induced oxidative significantly damaged the viability and membrane potential of mitochondrial compared with controls (P<0.05). Administration of nano-curcumin significantly increased the SOD activity, as well as viability and mitochondrial membrane potential in the PQ group (P<0.05). Besides, treatment by nano-curcumin in the PQ group significantly improved the lipid peroxidation process (P<0.05).
Conclusion: Nanocurcumin is more effective than curcumin in reducing the PQ-induced oxidative damage.
Materials and Methods: Thirty-six Wistar rats were used in this study. They were separated into 6 groups: control subjects and animals poisoned with PQ that received treatment with or without curcumin and nano-curcumin for 7 days. Liver mitochondria were isolated, and oxidative stress markers, including Total Antioxidant Capacity (TAC), Lipid Peroxidation (LPO), Catalase (CAT) and Superoxide Dismutase (SOD) activity, as well as viability and mitochondrial membrane potential, were assessed.
Results: Poisoning by PQ significantly increased the LPO levels and considerably decreased the TAC, CAT, and SOD activity compared with the control subjects (P<0.05). PQ-induced oxidative significantly damaged the viability and membrane potential of mitochondrial compared with controls (P<0.05). Administration of nano-curcumin significantly increased the SOD activity, as well as viability and mitochondrial membrane potential in the PQ group (P<0.05). Besides, treatment by nano-curcumin in the PQ group significantly improved the lipid peroxidation process (P<0.05).
Conclusion: Nanocurcumin is more effective than curcumin in reducing the PQ-induced oxidative damage.
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