Volume 8, Issue 1 (Feb 2020)                   Res Mol Med (RMM) 2020, 8(1): 0-0 | Back to browse issues page

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Eslamirad Z, Didehdar M, Moini A, Anoushirvani A. The Co-infection of Immunodeficiency with a Free-Living Amoeba: Acanthamoeba in BAL Samples. Res Mol Med (RMM). 2020; 8 (1)
Abstract:   (414 Views)
Background: Pulmonary disorders caused by parasites are common in many tropical regions. Acanthamoeba is an opportunistic parasite because most of its dangerous complication reported from patients with immune deficiencies.
Materials and methods: Considering the high dissemination of Acanthamoeba parasite in water, soil, and airborne fine dust in Iran, this research was performed to study the rate of pulmonary secretions infection to Acanthamoeba in a patient with immune system disorder. This cross-sectional study was done in one year (2017 to 2018) in Arak city. The study population was selected from an immunodeficient subject who had the chronic obstructive pulmonary disease (COPD). The respiratory sample was obtained from each selected patient by bronchoalveolar lavage (BAL) sample and demographic data were obtained. Each sample was examined by smear staining, cultivation, and molecular methods.
Results: Out of 64 immunocompromised patients investigated in current research, the Acanthamoeba infection was found in 100% and 98.4% by cultivation and molecular methods, respectively.
Conclusion: The outcomes of our research indicated that selecting the diagnostic method in agreement with the kind of sample has a remarkable role in recognizing the contamination. The outcomes of this research indicated that direct microscopy test of Giemsa stained smear was not suitable for detecting this kind of parasitic infection in the BAL sample. Therefore, awareness of the occurrence of Acanthamoebiasis in immunocompromised subjects is essential for preventing the dangerous complications of this parasite. 
Type of Study: Research | Subject: Parasitology
Received: 2019/12/17

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