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Volume 7, Issue 4 (Nov 2019)                   Res Mol Med (RMM) 2019, 7(4): 0-0 | Back to browse issues page

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Gholizade M, Fayazi J. Prediction of MicroRNAs bind to Toll-like Receptors Pathway in Chicken based on Bioinformatics Method. Res Mol Med (RMM). 2019; 7 (4)
URL: http://rmm.mazums.ac.ir/article-1-333-en.html
Abstract:   (845 Views)

Toll-like receptors (TLRs) recognize distinct pathogen-associated molecular patterns and play a critical role in innate immune responses. Activation of TLR-signaling pathways is required for hosts to eliminate invading pathogens. But excessive activation of these pathways may also disrupt immune homeostasis, leading to some diseases, therefore precise regulation of TLR-signaling pathways is important. Since miRNAs act as a class of small noncoding RNAs with gene regulatory functions, the regulation of TLR expression by miRNAs may one of the effective points for target TLRs. In this study, we predicted most of microRNAs bind to Toll-like receptors pathway in chicken based on bioinformatics method. Total genes involved in the TLR signaling pathway in chicken species were extracted from the KEGG database (Entry: gga04620) and analyzed based on bioinformatics software. We prediction 19 micro-RNA for the 18 target genes of TLR pathway that may provide important clues for identifying novel and attractive drug targets to inflammatory diseases.

     
Type of Study: Research | Subject: Genetic
Received: 2019/09/19

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