Volume 6, Issue 4 (Nov 2018)                   Res Mol Med (RMM) 2018, 6(4): 0-0 | Back to browse issues page

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Fotoohi M, Hadi N, Namazi F. Effect of Foretinib on the Matrix Metalloproteinase 2 (MMP2) Expression in Glioblastoma Cell Line. Res Mol Med (RMM). 2018; 6 (4)
Abstract:   (110 Views)
BACKGROUND: The most malignant form of infiltrating astrocytoma, glioblastoma multiforme (GBM), is one of the most aggressive human cancers. Foretinib diminished GBM cell invasion by impairing the matrix metalloproteinase (MMP).
AIM: The aim of this study was examining the anti-tumor activity of foretinib by the effect on MMP-2 expression in T98 cell line.
MATERIALS AND METHODS: In this experimental study, the T98 cell line was used as an experimental model of glioblastoma. The effect of foretinib on the expression changes of the MMP-2 gene was evaluated using quantitative real-time polymerase chain reaction (qRT-PCR). Then the effect of foretinib on the enzymatic levels of MMP was examined by zymography technique. Statistical analyses were performed with Graph Pad Prism software.
RESULTS: Results indicated a reduction in the expression of MMP-2 by increasing the concentration of foretinib.
CONCLUSION: Our results suggested foretinib leads to down-regulation of MMP-2 and has a positive effect on T98 cell lines. We believe that foretinib is useful for further clinical development for the treatment of GBM.
Type of Study: Research | Subject: Genetic
Received: 2019/04/21

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