Volume 7, Issue 1 (Feb 2019)                   Res Mol Med (RMM) 2019, 7(1): 8-15 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Amouzeshi A, Moossavi S Z, Javad Moosavi S Y, Zardast M, Malekaneh M, Esmaili S, et al . Aqueous Cannabis Extract Prevents Induced by Ethylene Glycol-induced Renal Calcium Crystallization . Res Mol Med (RMM). 2019; 7 (1) :8-15
Abstract:   (1234 Views)
BACKGROUND: Some plant extracts can prevent kidney stone formation in a dose-dependent manner. In our study, we aimed to investigate the protective role of Cannabis sativa aqueous extraction on calcium oxalate formation in ethylene glycol-induced rats.
MATERIALS AND METHODS: To evaluate anti-urolithiasis, variations of the main risk factors (citrate, phosphorous, calcium, and Ph) have been evaluated in 24-hour urine samples of rats one day before the end of the experiment. Rats were divided into 4 groups: group 1 was administered regular drinking water; group 2 was administered 1% ethylene glycol in drinking water, group 3 was administered 100 mg/kg of Cannabis sativa extract for oral administration by gavage along with drinking water containing 1% ethylene glycol; and group 4 was administered 200 mg/kg of Cannabis sativa extract by gavage along with drinking water containing 1% ethylene glycol. Finally, histopathological slides from the kidney were also evaluated.
RESULTS: Results showed that 100 mg/kg and 200 mg/kg doses of Cannabis sativa extract significantly reduced the mentioned risk factors in comparison with ethylene glycol-treated rats (p<0.05).
 CONCLUSION: Histopathological slides showed reduced calcifications with extract treatment at 200 mg/kg of Cannabis sativa. Thus, this antioxidant herb can prevent kidney stone formation. These findings pave the way for new therapy.
Full-Text [PDF 762 kb]   (305 Downloads)    
Type of Study: Research | Subject: Internal Medicine
Received: 2019/03/24 | Published: 2019/02/15

Add your comments about this article : Your username or Email:

Send email to the article author

© 2021 All Rights Reserved | Research in Molecular Medicine

Designed & Developed by : Yektaweb