COPE
Volume 7, Issue 1 (Feb 2019)                   Res Mol Med (RMM) 2019, 7(1): 0-0 | Back to browse issues page

XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Amouzeshi A, Moossavi S Z, Javad Moosavi S Y, Zardast M, Malekaneh M, Esmaili S, et al . Preventive Effects of Cannabis Sativaon Renal Calcium Crystallization Induced by Ethylene Glycol in Rats. Res Mol Med (RMM). 2019; 7 (1)
URL: http://rmm.mazums.ac.ir/article-1-297-en.html
Abstract:   (77 Views)
BACKGROUND: Some herbal plants can prevent kidney stones formation in a dose dependent manner. In present study, we aimed to investigate the protective role of Cannabis sativa aqueous extraction on calcium oxalate formation in ethylene glycol-induced rats.
MATERIALS AND METHODS: To evaluate anti-urolithiasis, variations of the main risk factors (citrate, phosphorous, calcium and PH) have been evaluated one day before the end of the experiment from the 24-hour urine samples of rats. Rats classified in 4 groups; group1: regular drinking water; group 2: 1% ethylene glycolin drinking water, group 3: 100 mg / kg dose of cannabis sativa extract for oral administration by gavage along with drinking water containing 1% ethylene glycol and group 4: 200 mg/kg dose of cannabis sativa extract by gavage along with drinking water containing 1% ethylene glycol. Finally, the histophatological slides from the kidney were also evaluated.
RESULTS: Results showed that 100 mg/kg and 200 mg/kg doses of Cannabis sativa extract reduced the mentioned risk factors statistically significant in comparison with ethylene glycol induced rats (p<0.05).
 CONCLUSION: Histopathogical slides showed reduced calcifications with extract treatment at 200 mg/kg of Cannabis sativa. It seems that this antioxidant herb can mediate prevention of kidney stones formation and paves the way for new therapy.
     
Type of Study: Research | Subject: Internal Medicine
Received: 2019/03/24

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


© 2019 All Rights Reserved | Research in Molecular Medicine

Designed & Developed by : Yektaweb