Volume 6, Issue 3 (Aug 2018)                   Res Mol Med (RMM) 2018, 6(3): 0-0 | Back to browse issues page

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Sadeghi-Amiri L, Barzegar A, Rafiei A, Amjadi O. An overview on the epigenetic modifications of gene expression in tumorigenesis. Res Mol Med (RMM). 2018; 6 (3)
Abstract:   (271 Views)
The top five most common causes of cancer related deaths are cancers of lung (1.76 million deaths), colorectal (862,000 deaths), stomach (783,000 deaths), liver (782,000 deaths) andbreast (627,000 deaths).Epigenetic changes canalterthe chromatin compactionleading to the regulation of geneexpression without changing the primary DNA sequence.Epigenetic mechanisms are normally involved inprocedures like genomic stability, chromosome X inactivation, and embryonic development and differentiation. The role of DNA methylation just asother types of chromatin modifications has been demonstrated to affect the expression of various genes. Any impairment in these mechanisms alters gene expression regulation which might contributeto the malignant cell transformation. Over the past few years,extensive innovationsin epigenetics have encouraged its applicationas a main strategy fortreatmentof important diseases like cancer.

Type of Study: review | Subject: Genetic
Received: 2019/03/17

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