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Volume 6, Issue 3 (Aug 2018)                   Res Mol Med (RMM) 2018, 6(3): 0-0 | Back to browse issues page

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Namazi F, Hadi N, Moghimi M, Eshaghiyan A, Nateghi B. Down-regulation of miR-193b-3p and miR-376a-3p in Chronic Lymphocytic Leukemia. Res Mol Med (RMM). 2018; 6 (3)
URL: http://rmm.mazums.ac.ir/article-1-288-en.html
Abstract:   (946 Views)
Background: Chronic lymphocytic leukemia (CLL) is the most common adult human leukemia.  MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression. Studies revealed microRNAs can function as oncogenes or tumor suppressors in CLL. Also, it has demonstrated that the expression of miR-193b-3p and miR-376a-3p change in several diseases. However, the prognostic value of these miRNAs in CLL is still unknown.
We describe the effect of the regulating miR-193b-3p and miR-376a-3p on the prognosis of CLL by quantitative real-time PCR.
 Methods: We profiled miR-193b-3p and miR-376a-3p expression by quantitative real-time PCR in peripheral blood mononuclear cells (PBMCs) of 30 patients with CLL and 30 healthy individuals. Moreover, in silico molecular enrichment analysis was conducted on predicted and validated targets of miR-193b-3p and miR-376a-3p in the miRecords and miRTarBase databases.
Results: The expression of miR-193b-3p and miR-376a-3p was significantly different between the two studied groups (P<0.0001 and P < 0.0001, respectively).
Conclusion: Based on the findings, miR-193b-3p and miR-376a-3p are probably two new potential biomarkers for the early diagnosis of patients with CLL or as a molecular goal in designing new CLL control strategies.
     
Type of Study: Research | Subject: Hematology & Oncology
Received: 2019/02/13

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