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Volume 6, Issue 2 (May 2018)                   Res Mol Med (RMM) 2018, 6(2): 0-0 | Back to browse issues page

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farzanegi P, dehghan A, abbaszadeh H. Effects of continuous and interval exercises on blood glucose and insulin contents and expression of IL-6 and GLUT4 in skeletal muscle of diabetic rats . Res Mol Med (RMM). 2018; 6 (2)
URL: http://rmm.mazums.ac.ir/article-1-284-en.html
Abstract:   (188 Views)
Background and objective: Diabetes mellitus is one of the most common metabolic disorders worldwide. We considered the effect of continuous and interval exercises on the blood glucose and insulin contents as well as the expression of interleukin-6 (IL-6) and GLUT4 in skeletal muscle of diabetic rats. Methods: Streptozotocin-induced old diabetic rats were randomly divided into 3 groups, including patient, interval exercise (HIT) and continuous exercise (MIT) groups. Blood insulin level was measured using a specific ELISA Kit. Blood glucose was determined by Autoanalyzer apparatus. Expression of IL-6 and GLUT4 genes was considered using RT-PCR. Data were analyzed using SPSS software. Results: Diabetes was significantly associated with IL-6 and GLUT4 downregulation in skeletal muscle of rats (p<0.001). Continuous (9975.41-fold; p=0.000) and interval (7113.91-fold; p=0.000) exercises significantly increased the expression of IL-6 compared to the patient group. Furthermore, continuous (9.36-fold; p=0.000) and interval (7.65-fold; p=0.001) exercises significantly increased the expression of GLUT4 compared to the patient group. Exercises training were associated with a significant decrease in the blood glucose and insulin contents compared to the patient group (p<0.0001). Conclusions: Diabetes was significantly associated with IL-6 and GLUT4 downregulation. Continuous and interval exercises significantly increased the expression of IL-6 and GLUT4, while blood glucose and insulin contents were decreased.
     
Type of Study: Research | Subject: Phisiology
Received: 2019/01/3 | Accepted: 2019/01/22

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