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Volume 6, Issue 3 (Aug 2018)                   Res Mol Med (RMM) 2018, 6(3): 0-0 | Back to browse issues page

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Zafari J, Vazini H, Javani-jouni F, Abdolmaleki P, Monajemi R, Shams E et al . Evaluation of the Anticancer Effects of Moderate Static Magnetic Field on the Viability, Proliferation Rate and Lipid Peroxidation of Cancer and Normal Cells. Res Mol Med (RMM). 2018; 6 (3)
URL: http://rmm.mazums.ac.ir/article-1-282-en.html
Abstract:   (201 Views)
Backgrounds: Static and time-varying magnetic field is widely distributed in the environment and their effects are interesting. Humans, animals, plants and all living organisms on Earth has evolved in this field and been used from the beginning. But with advances in science and technology and expanding the use of magnetic fields in metals, mining industry, transport, research, medicine and so create a new discussion in which the magnetic field strength is negligible and its effects cannot be ignored.
Methods: The effect of magnetic field on viability, proliferation rate and membrane lipid peroxidation were studied. For this purpose, HeLa cell lines and human fibroblast cells (normal cells) were used. Initially the cells were cultured in DMEM medium and to determine the impact intensity and timing of magnetic field intensities (7, 14 and 21 mT) and 2 times (24 and 48) were selected and the cells were treated with magnetic field. Viability percent and inhibition of cell proliferation were calculated by MTT assay, and staining with Trypan blue, respectively.
Results: Lipid peroxidation of cell membrane was examined by malon dialdehyde method. Increasing of intensity and time of static magnetic field (SMF)-exposure decreased the viability percent and proliferation rate and increased the Lipid peroxidation in Hela cells.
Conclusion: In this study was shown anticancer effects of static magnetic field and was selected a suitable intensity range that can be effective for future use in the treatment of cancer.
 
     
Type of Study: Research | Subject: Biology
Received: 2018/12/31

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