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Volume 6, Issue 1 (Feb 2018)                   Res Mol Med (RMM) 2018, 6(1): 0-0 | Back to browse issues page

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Sheikhalizadeh V, Ahangarzadeh Rezaee M, Langarizadeh N. Different features of Escherichia coli and Klebsiella pneumoniae in children and adults. Res Mol Med (RMM). 2018; 6 (1)
URL: http://rmm.mazums.ac.ir/article-1-273-en.html
Abstract:   (203 Views)
Background: This study aimed to describe the association between age groups and antimicrobial susceptibility patterns, also integron presence in Escherichia coli and Klebsiella pneumoniae  isolates from Tabriz, Iran.
Materials and methods: 140 isolates of E. coli and 150 isolates of K. pneumoniae, both comprising the same number of children and adult isolates were examined for susceptibility to 13 routine antibiotics. The integron existence in multidrug resistant (MDR) isolates was also determined using PCR-RFLP.
Results: The significant age related differences were observed in the resistant rates of K. pneumoniae toward cotrimoxazol, nalidixic acid, ciprofloxacin and norfloxacin. For E. coli, age related differences in resistance rates to tetracycline, chloramphenicol, ciprofloxacin and norfloxacin were significant. PCR-RFLP results revealed intI1 presence in 24.5% and 19.2% of MDR E. coli in children and adults, respectively. In K. pneumoniae, 72.9% of children and 84% of adults isolates were positive for intI1. The prevalence of class 2 integrons was significantly associated with age group, in both E. coli and K. pneumoniae. No class 3 integrons were detected in this study.
Conclusions: The resistance rates differ across age groups. Moreover, this study is the first to demonstrate age related differences in the integron presence, especially class 2 integrons, in E. coli and K. pneumoniae.
 
     
Type of Study: Research | Subject: Microbiology
Received: 2018/08/14 | Accepted: 2018/09/1

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