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Volume 6, Issue 1 (Feb 2018)                   Res Mol Med (RMM) 2018, 6(1): 0-0 | Back to browse issues page

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Sheikhalizadeh V, Ahangarzadeh Rezaee M, Langarizadeh N, Goli H R. Different Features of Escherichia coli and Klebsiella pneumoniae in Children and Adults. Res Mol Med (RMM). 2018; 6 (1)
URL: http://rmm.mazums.ac.ir/article-1-273-en.html
Abstract:   (424 Views)
Background: This study aimed to describe the association between age groups and antimicrobial susceptibility patterns, also integron presence in Escherichia coli and Klebsiella pneumoniae  isolates from Tabriz, Iran.
Materials and methods: Equal numbers of isolates from adults and children, 140 for E. coli and 150 for K. pneumoniae, were examined for susceptibility to 13 routine antibiotics. Integron existence in multidrug resistant (MDR) isolates was also determined using PCR-RFLP.
Results: Significant age-related differences were observed in the resistance rates of K. pneumoniae toward cotrimoxazol, nalidixic acid, ciprofloxacin, and norfloxacin. For E. coli, age-related differences in the resistance rates to tetracycline, chloramphenicol, ciprofloxacin, and norfloxacin were significant. PCR-RFLP results revealed the presence of class 1 integron (intI1) in 24.5% and 19.2% of MDR E. coli in children and adults, respectively. In K. pneumoniae, 72.9% of isolates from children and 84% from adults were positive for intI1. The prevalence of class 2 integrons was significantly associated with age, in both E. coli and K. pneumoniae. No class 3 integrons were detected in this study.
Conclusions: The resistance rates differ across age groups. Moreover, this study is the first to demonstrate age-related differences in integron presence, especially for class 2 integrons, in E. coli and K. pneumoniae.
 
Full-Text [PDF 426 kb]   (66 Downloads)    
Type of Study: Research | Subject: Microbiology
Received: 2018/08/14 | Accepted: 2018/09/1

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