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Volume 3, Number 2 (Mar 2015)                   Res Mol Med (RMM) 2015, 3(2): 22-27 | Back to browse issues page



DOI: 10.7508/rmm.2015.02.004

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Askari M, Nikpoor A R, Aryan H, Ghaedi H, Akhtari J, Azarnejad A, et al . Association of Apolipoprotein E Alleles with Susceptibility to Age-Related Macular Degeneration in Iranian Patients. Res Mol Med (RMM). 2015; 3 (2) :22-27
URL: http://rmm.mazums.ac.ir/article-1-142-en.html

Abstract:   (1842 Views)

Background: We aimed here to investigate the association between alleles and genotypes of APOE and Age-related macular degeneration (AMD) development.
Materials and Methods: After ophthalmological examination, 120 patients with confirmed AMD and 120 healthy controls were enrolled in the study. The polymorphic segment of APOE gene was PCR-amplified and sequenced to determine the frequency distribution of polymorphic alleles and genotypes of this gene in the sample population.
Results: The frequency distribution of APOE alleles and genotypes differed significantly between the patients and the control groups (P<0.05). The frequency of APOE&epsilon2 in patients was higher than controls (P = 0.00) and this variant allele showed a significant association with AMD even after removal of the effects of age, sex and smoking by logestic regression analysis (P = 0.00, OR= 3.439 CI 95% 1.664-7.108). On the other hand, the frequency distribution of APOE&epsilon4 was not statistically different between patients and healthy controls.
Conclusion: The results show a moderate positive association between APOE &epsilon2 and AMD, but current data does not show any role for APOE &epsilon4 in protection from AMD. However, more studies are required to reveal the possible role of APOE in the pathogenesis of AMD.

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Type of Study: Research | Subject: Molecular biology
Received: 2015/05/23 | Accepted: 2015/05/31 | Published: 2015/05/31

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