COPE
Volume 3, Number 3 (Jul 2015)                   Res Mol Med (RMM) 2015, 3(3): 33-37 | Back to browse issues page



DOI: 10.7508/rmm.2015.03.007

XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Mahdavi M R, Haghshenas M R, Roshan P, Hojjati M T, Mahdavi M, Jalali H et al . Is Quantitative HBsAg Measurement a Reliable Substitute for HBV DNA Quantitation?. Res Mol Med (RMM). 2015; 3 (3) :33-37
URL: http://rmm.mazums.ac.ir/article-1-127-en.html

Abstract:   (1658 Views)

Background: Hepatitis B surface antigen (HBsAg) is one of the main proteins of HBV envelop and its serum quantitative measurement is the most common quantitative test for monitoring the progress of Chronic Hepatitis B. Although measurement of serum HBV DNA copy number is a gold standard method for displaying viral load, the test is relatively expensive and it is not readily available everywhere in the world, while quantitative detection of HBsAg is fairly easy and inexpensive. The aim of this study was to investigate the correlation between serum HBsAg level and HBV DNA copy number in patients with chronic HB.
Materials and Methods: Quantitative HBsAg, quantitative HBV DNA, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) serum levels were tested in 74 patients with chronic hepatitis B infection - who were HBsAg-positive for more than 6 months. In order to find any correlation between the results of these methods, Spearman and Kruska-Wallis correlation coefficient tests were applied.
Results: No significant correlation was observed between quantitative HBsAg and HBV DNA measurements. Also, we could not find any correlation between serum HBsAg and ALT levels. But, serum HBV DNA content and AST level had a significant positive correlation.
Conclusion: There are many factors affecting the correlation between serum HBV DNA copy number and HBsAg level such as genotype of HBV virus, phase of infection, methods of measurement, HBeAg status, and drug and types of treatment procedures. Therefore, these factors should be considered in further studies dealing with the correlation between quantitative HBV DNA and HBsAg tests.

Full-Text [PDF 538 kb]   (649 Downloads)    
Type of Study: Research | Subject: Medical Virology
Received: 2015/04/8 | Accepted: 2015/09/16 | Published: 2015/09/16

Add your comments about this article : Your username or email:
Write the security code in the box

Send email to the article author


© 2015 All Rights Reserved | Research in Molecular Medicine

Designed & Developed by : Yektaweb