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Volume 3, Number 1 (Feb 2015)                   Res Mol Med (RMM) 2015, 3(1): 18-23 | Back to browse issues page



DOI: 10.7508/rmm.2015.01.004

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Kazemipour A, Goliaei B, Pezeshk H, Kalantari khandani B. Identification and prioritization genes related to Hypercholesterolemia QTLs using gene ontology and protein interaction networks. Res Mol Med (RMM). 2015; 3 (1) :18-23
URL: http://rmm.mazums.ac.ir/article-1-112-en.html

Abstract:   (2247 Views)

Gene identification represents the first step to a better understanding of the physiological role of the underlying protein and disease pathways, which in turn serves as a starting point for developing therapeutic interventions. Familial hypercholesterolemia is a hereditary metabolic disorder characterized by high low-density lipoprotein cholesterol levels. Hypercholesterolemia is a quantitative trait that is controlled by interactions among several quantitative trait loci. Many biological data is presented in the context of biological networks and evaluation of biological networks is considered as the essential key to understanding complex biological systems. In this research, we used combination of information about quantitative trait loci of hypercholesterolemia with information of gene ontology and protein–protein interaction network for identification of genes associated with hypercholesterolemia. For this disease, we introduced 16 new genes which were in quantitative trait loci regions and were associated with the hypercholesterolemia disease in terms of gene ontology characteristics.

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Type of Study: Research | Subject: Genetic
Received: 2014/12/18 | Accepted: 2015/02/27 | Published: 2015/02/27

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