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Volume 2, Number 4 (Nov 2014)                   Res Mol Med (RMM) 2014, 2(4): 24-29 | Back to browse issues page




DOI: 10.18869/acadpub.rmm.2.4.24

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Torabizadeh Z, Nadji A, Naghshvar F, Nosrati A, Parsa M. Association between Epstein - Barr Virus (EBV) and Breast Cancer. Res Mol Med (RMM). 2014; 2 (4) :24-29
URL: http://rmm.mazums.ac.ir/article-1-104-en.html

Abstract:   (2072 Views)

Background: Breast cancer is the most common malignancy in females worldwide. Several etiological factors including environmental factors have been recognized for breast cancer. Epstein Barr virus as a viral etiological factor has been proposed. So far, several studies have investigated the relationship between development of breast cancer and Epstein Barr virus, but few have been done in Iran. The aim of this study was to determine whether there was an association between EBV infection and female breast cancer in Iran.

Materials and Methods: We analyzed paraffin embedded breast tissue specimens by polymerase chain reaction (PCR) including breast cancer specimens (as case group) and breast fibroadenoma specimens (as control group). PCR was performed to amplify specific sequences of EBV.

Results: From 130 cases of breast samples, 67 cases of breast cancer tissues and 41 cases of breast fibroadenoma tissues had adequate quality and quantity of DNA to detect EBV. PCR for EBV was positive in 4 invasive ductal carcinoma specimens (7.3%) and only one of the fibroadenoma specimens (2.4%). No significant association was found between EBV infection and invasive ductal carcinoma (p> 0.05). Also, patient’s age and histological grade of IDC were not correlated with EBV infection (p>0.05).

Conclusion: We observed no etiologic association between EBV infection and invasive ductal carcinoma of female breast in our regions however, further studies are required to elucidate this association .

Full-Text [PDF 451 kb]   (720 Downloads)    
Type of Study: Research | Subject: Pathology
Received: 2014/10/24 | Accepted: 2014/10/24 | Published: 2014/10/24

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