Among the vast variety of radionuclides available, a handful of them possess proper features for targeted alpha therapy (TAT). TAT holds the promise of exceeding the effectiveness of conventional radiotherapy methods. Actinium-225 is considered to be an outstanding isotope for TAT in the management of cancer due to its half-life, which enables sustained delivery at the tumor site. This review covers the clinical applications of actinium-225 radiopharmaceuticals.