Volume 13, Issue 1 (Feb 2025)
Res Mol Med (RMM) 2025, 13(1): 9-22 |
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Hojat A, Enderami S E, Nassiri Mansour R, Kabi M, Abazari M, Mehdipour Chari K, et al . New Insights and Perspectives on Human Menstrual Blood-derived Stem Cells as a New Cell-based Delivery Technology in Regenerative Medicine. Res Mol Med (RMM) 2025; 13 (1) :9-22
URL: http://rmm.mazums.ac.ir/article-1-589-en.html
URL: http://rmm.mazums.ac.ir/article-1-589-en.html
Atefeh Hojat1 
, Seyed Ehsan Enderami2 , Reyhaneh Nassiri Mansour3 , Mohammad Kabi1 , Mohamadfoad Abazari4 , Keyvan Mehdipour Chari1 , Amirali Khodashenas1 , Vahid Kia5 , Amir Maleksabet1
, Seyed Ehsan Enderami2 , Reyhaneh Nassiri Mansour3 , Mohammad Kabi1 , Mohamadfoad Abazari4 , Keyvan Mehdipour Chari1 , Amirali Khodashenas1 , Vahid Kia5 , Amir Maleksabet1
1- Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
2- Department of Medical Biotechnology, Immunogenetics Research Center, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran. ,ehsan.enderami@gmail.com
3- Department of Medical Biotechnology, Immunogenetics Research Center, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
4- Department of Neurosciences, University of British Columbia, Vancouver, Canada.
5- Department of Medical Biotechnology, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.
2- Department of Medical Biotechnology, Immunogenetics Research Center, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran. ,
3- Department of Medical Biotechnology, Immunogenetics Research Center, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
4- Department of Neurosciences, University of British Columbia, Vancouver, Canada.
5- Department of Medical Biotechnology, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.
Abstract: (1051 Views)
Background: Menstrual blood has been identified as an important source for the isolation of mesenchymal stem cells (MSCs). These stem cells can easily and non-invasively be harvested from menstrual blood during menstrual shedding. There has been extensive research on the differentiation potential of menstrual blood-derived stem cells (MenSCs) and their application in regenerative medicine and the treatment of diseases.
Materials and Methods: The aim of this paper was to review the current and future application of MenSCs in the field of regenerative medicine and cell therapy based on an electronic search in various databases, like Scopus, PubMed, and Google Scholar for English-language studies. The application of MenSCs in regenerative medicine can be the window of hope for the treatment of various diseases and disabilities, such as female infertility, type 1 diabetes, myocardial infarction, wound healing, neurodegenerative diseases, and many other conditions that were thought to be incurable in the past.
Conclusion: Nowadays, the use of MenSC as a novel source of MSCs has garnered special interest among scientists due to two important factors: Non-invasive accessibility and the immunomodulatory potential of these cells, which have historically posed significant obstacles in the field of stem cell therapy. To date, there has been substantial research on these cells, and many studies are ongoing, as scientists seek to leverage their differentiation potential and optimize differentiation conditions and protocols for their application in regenerative medicine.
Materials and Methods: The aim of this paper was to review the current and future application of MenSCs in the field of regenerative medicine and cell therapy based on an electronic search in various databases, like Scopus, PubMed, and Google Scholar for English-language studies. The application of MenSCs in regenerative medicine can be the window of hope for the treatment of various diseases and disabilities, such as female infertility, type 1 diabetes, myocardial infarction, wound healing, neurodegenerative diseases, and many other conditions that were thought to be incurable in the past.
Conclusion: Nowadays, the use of MenSC as a novel source of MSCs has garnered special interest among scientists due to two important factors: Non-invasive accessibility and the immunomodulatory potential of these cells, which have historically posed significant obstacles in the field of stem cell therapy. To date, there has been substantial research on these cells, and many studies are ongoing, as scientists seek to leverage their differentiation potential and optimize differentiation conditions and protocols for their application in regenerative medicine.
Keywords: Regenerative medicine, Menstrual blood-derived stem cells (MenSCs), Mesenchymal stem cell (MSC), Stem cell therapy
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