Volume 11, Issue 2 (May 2023)
Res Mol Med (RMM) 2023, 11(2): 103-112 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Ardebilifard A, Hoseinnejad A, Jafarzade J, Hajizadeh Jouybari N, Rajabnia Baboli A, Khalilpour A, et al . Investigating the Antifungal Effects of Spirocyclopropane Oxindoles Derivatives Against Aspergillus Species. Res Mol Med (RMM) 2023; 11 (2) :103-112
URL: http://rmm.mazums.ac.ir/article-1-508-en.html
URL: http://rmm.mazums.ac.ir/article-1-508-en.html
Amirreza Ardebilifard1 
, Akbar Hoseinnejad2 , Jalal Jafarzade3 , Nava Hajizadeh Jouybari1 , Aida Rajabnia Baboli1 , Asieh Khalilpour4 , Firoozeh Kermani3 , Aryan Yousefifard5 , Mojtaba Taghizadeh Armaki 6
, Akbar Hoseinnejad2 , Jalal Jafarzade3 , Nava Hajizadeh Jouybari1 , Aida Rajabnia Baboli1 , Asieh Khalilpour4 , Firoozeh Kermani3 , Aryan Yousefifard5 , Mojtaba Taghizadeh Armaki 6
1- Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
2- Department of Medical Mycology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
3- Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
4- Department of Environmental Health Engineering, School of Public Health, Babol University of Medical Sciences, Babol, Iran.
5- Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran & Department of Pharmaceutics, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
6- Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran ,mojtabataghizade@yahoo.com
2- Department of Medical Mycology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
3- Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
4- Department of Environmental Health Engineering, School of Public Health, Babol University of Medical Sciences, Babol, Iran.
5- Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran & Department of Pharmaceutics, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
6- Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran ,
Abstract: (759 Views)
Background: Given the increasing resistance of Aspergillus spp. to azoles, finding effective new compounds, such as the spirocyclopropane oxindoles (4a-4b-4c) derivatives, seems necessary. The present study aimed to evaluate the antifungal activity of spirocyclopropane oxindoles (4a-4b-4c) derivatives against Aspergillus spp.
Methods: In vitro, the cytotoxicity of the synthesized compounds was evaluated against MCF-7 cancer cell lines using the MTT assay. In the next step, the antifungal susceptibility of 50 Aspergillus isolates of clinical origin to spirocyclopropane oxindoles (4a-4b-4c) derivatives and itraconazole was evaluated according to CLSI (Clinical and Laboratory Standards Institute) M38A2 guidelines. Statistical analysis was performed using SPSS software, version 20, and the significance level was considered P<0.05.
Results: The results revealed that 4c exhibited the lowest toxicity to MCF-7 cells among the three synthesized compounds. However, this level of toxicity was higher than control. The present study shows a significant difference between the minimum inhibitory concentration (MIC) of 4a-4b-4c oxindole derivatives of spirocyclopropane and itraconazole against Aspergillus spp. Comparing the MIC values of 4a, 4b, and 4c oxindole spirocyclopropane derivatives with each other, 4b derivatives have lower MIC values for Aspergillus flavus and Aspergillus fumigatus isolates. In addition, 4c derivatives had the highest MIC for Aspergillus terreus.
Conclusion: Although the antifungal effects of spirocyclopropane oxindoles (4a-4b-4c) on Aspergillus spp. were significantly lower than itraconazole, we hope to increase the antifungal effects of these compounds with structural changes.
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
This is an open access article distributed under the terms of the Creative Commons Attribution License (CC-By-NC), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Contact Information
