Volume 11, Issue 2 (May 2023)                   Res Mol Med (RMM) 2023, 11(2): 0-0 | Back to browse issues page

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Ardebilifard A, Hoseinnejad A, Jafarzade J, Hajizadeh Jouybari N, Rajabnia Baboli A, Khalilpour A, et al . Investigating the Antifungal Effects of Spirocyclopropane Oxindoles Derivatives Against Aspergillus Species. Res Mol Med (RMM) 2023; 11 (2)
URL: http://rmm.mazums.ac.ir/article-1-508-en.html
1- Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
2- Department of Medical Mycology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
3- Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
4- Department of Environmental Health Engineering, School of Public Health, Babol University of Medical Sciences, Babol, Iran.
5- Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran & Department of Pharmaceutics, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
6- Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran , mojtabataghizade@yahoo.com
Abstract:   (197 Views)
Introduction: Given the increasing resistance of Aspergillus spp to azoles, it is important to find new compounds that are effective, such as the spirocyclopropane oxindoles (4a-4b-4c) derivatives. The aim of the present study was to evaluate the antifungal activity of spirocyclopropane oxindoles (4a-4b-4c) derivatives against Aspergillus spp.
Methods: In vitro cytotoxicity of the synthesized compounds was evaluated against MCF-7 cancer cell lines using the MTT assay. In the next step, the antifungal susceptibility of 50 Aspergillus isolates of clinical origin to spirocyclopropane oxindoles (4a-4b-4c) derivatives and itraconazole was evaluated according to CLSI M38A2 guidelines. Statistical analysis was performed using SPSS20 software and the significance level was considered as P < 0.05.
Results:The results revealed that among the three synthesized compounds, 4c exhibited the lowest toxicity to MCF-7 cells. However, this level of toxicity was higher than control.
 In the present study, there is a significant difference between the MIC values of 4a-4b-4c oxindole derivatives of spirocyclopropane and itraconazole against Aspergillus spp. Comparing the MIC values of 4a, 4b and 4c oxindole spirocyclopropane derivatives with each other (4a-4b-4c), 4b derivatives have lower MIC values for Aspergillus flavus and Aspergillus fumigatus isolates. In addition, 4c derivatives had the highest MIC for Aspergillus terreus.
Conclusion: Although the antifungal effects of Spirocyclopropane Oxindoles (4a-4b-4c) on Aspergillus spp were significantly lower than itraconazole, but with structural changes, we can hope to increase the antifungal effects of these compounds.
     
Type of Study: Research | Subject: Mycology
Published: 2023/05/30

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