دوره 2، شماره 3 - ( تابستان 1393 )                   جلد 2 شماره 3 صفحات 10-1 | برگشت به فهرست نسخه ها


XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Moazeni M, Nabili M, Badali H, Abastabar M. RNAi technology: A Novel approaches against fungal infections. Res Mol Med (RMM) 2014; 2 (3) :1-10
URL: http://rmm.mazums.ac.ir/article-1-86-fa.html
RNAi technology: A Novel approaches against fungal infections. Research in Molecular Medicine. 1393; 2 (3) :1-10

URL: http://rmm.mazums.ac.ir/article-1-86-fa.html


چکیده:   (7871 مشاهده)

Despite the introduction of new antifungal agents, resistances to antifungal therapy continue to increase and outcome of invasive fungal infections treatment is frequently suboptimal. A large amount of the recent effort in antifungal drug discovery has focused on a limited set of targets with functions known or expected to be important for fungal viability and virulence. A variety of techniques can be used to identify fungal genes of interest. Gene expression profiling, RNA mediated gene silencing and insertional mutagenesis are three main molecular genetics technologies used to identify and validate antifungal drug targets. The term RNA interference (RNAi) refers to a cellular process by which a sequence-specific double-stranded RNA (dsRNA) inhibits the expression of a gene. This mechanism is strongly conserved in eukaryotes and has been documented to be existed in different fungal species such as Candida albicans, Aspergillus nidulans and Penicillium marneffei. Many vital and virulence genes have been successfully knocked down using RNAi technology. RNAi can be regarded as a promising approach for discovery of new gene targets for the design of fungus-specific antifungal agents. Here we discuss about a novel approach and its application in designing new molecular antifungal targets.

متن کامل [PDF 692 kb]   (3996 دریافت)    
نوع مطالعه: review | موضوع مقاله: قارچ شناسي
انتشار: 1393/5/15

ارسال نظر درباره این مقاله : نام کاربری یا پست الکترونیک شما:
CAPTCHA

بازنشر اطلاعات
Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.

کلیه حقوق این وب سایت متعلق به Research in Molecular Medicine می باشد.

طراحی و برنامه نویسی : یکتاوب افزار شرق

© 2024 CC BY-NC 4.0 | Research in Molecular Medicine

Designed & Developed by : Yektaweb