Volume 11, Issue 4 (Nov 2023)
Res Mol Med (RMM) 2023, 11(4): 265-272 |
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Parastesh M, Aria B. The Role of Moderate-intensity Continuous Exercise in Reducing Liver Enzyme Levels and Lipid Dysregulation in Platinol-induced Rats. Res Mol Med (RMM) 2023; 11 (4) :265-272
URL: http://rmm.mazums.ac.ir/article-1-554-en.html
URL: http://rmm.mazums.ac.ir/article-1-554-en.html
1- Department of Sports Physiology, Faculty of Sports Sciences, Arak University, Arak, Iran.
2- Department of Sport Sciences, Faculty of Psychology and Educational Sciences, Yazd University, Yazd, Iran. ,b.aria@yazd.ac.ir
2- Department of Sport Sciences, Faculty of Psychology and Educational Sciences, Yazd University, Yazd, Iran. ,
Abstract: (508 Views)
Background: Platinum-based chemotherapy, a cornerstone in cancer treatment, can induce hepatotoxicity. Exercise can mitigate adverse effects of chemotherapy, including liver damage. This study aimed to investigate the protective effects of moderate-intensity continuous training (MICT) on liver function and lipid metabolism in rats induced with Platinol.
Materials and Methods: Twenty-four male Sprague-Dawley rats were randomly divided into four groups: A healthy control group, a platinol-injected control group, a MICT group, and a platinolinjected group with MICT. Serum liver enzymes alkaline phosphatase (ALP), alanine transaminase (ALT), aspartate aminotransferase (AST) and lipid profiles were measured after 10 weeks of training or platinol injection.
Results: MICT significantly reduced serum levels of AST, ALT and ALP in platinol-induced rats, comparable to healthy controls. Additionally, MICT improved lipid profiles by reducing cholesterol, triglycerides, and low-density lipoprotein cholesterol while increasing high-density lipoprotein cholesterol (HDL).
Conclusion: MICT may be a promising intervention to mitigate platinum-induced liver toxicity and dyslipidemia. Further research is warranted to explore the potential clinical implications of these findings for cancer patients undergoing chemotherapy.
Materials and Methods: Twenty-four male Sprague-Dawley rats were randomly divided into four groups: A healthy control group, a platinol-injected control group, a MICT group, and a platinolinjected group with MICT. Serum liver enzymes alkaline phosphatase (ALP), alanine transaminase (ALT), aspartate aminotransferase (AST) and lipid profiles were measured after 10 weeks of training or platinol injection.
Results: MICT significantly reduced serum levels of AST, ALT and ALP in platinol-induced rats, comparable to healthy controls. Additionally, MICT improved lipid profiles by reducing cholesterol, triglycerides, and low-density lipoprotein cholesterol while increasing high-density lipoprotein cholesterol (HDL).
Conclusion: MICT may be a promising intervention to mitigate platinum-induced liver toxicity and dyslipidemia. Further research is warranted to explore the potential clinical implications of these findings for cancer patients undergoing chemotherapy.
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