Volume 11, Issue 1 (Mar 2023)
Res Mol Med (RMM) 2023, 11(1): 57-66 |
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Hajali V, Payvar B, Fattahi A, Izad Panah K A, Esfahani H, Saburi E et al . Clinical and Laboratory Characteristics of Hospitalized Patients With COVID-19 After Vaccination in Quchan-Iran. Res Mol Med (RMM) 2023; 11 (1) :57-66
URL: http://rmm.mazums.ac.ir/article-1-505-en.html
URL: http://rmm.mazums.ac.ir/article-1-505-en.html
Vahid Hajali 
1, Bahareh Payvar2 , Alireza Fattahi3 , Kosar al-Zahra Izad Panah3 , Hanieh Esfahani2 , Ehsan Saburi4 , Zahra Fard Tadaion5
1, Bahareh Payvar2 , Alireza Fattahi3 , Kosar al-Zahra Izad Panah3 , Hanieh Esfahani2 , Ehsan Saburi4 , Zahra Fard Tadaion5
1- Department of Nursing, Quchan School of Nursing, Mashhad University of Medical Sciences, Quchan, Iran. , hajaliv@mums.ac.ir
2- Department of Nursing, Quchan School of Nursing, Mashhad University of Medical Sciences, Quchan, Iran.
3- Student Research Committee, Quchan School of Nursing, Mashhad University of Medical Sciences, Quchan, Iran.
4- Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
5- Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
2- Department of Nursing, Quchan School of Nursing, Mashhad University of Medical Sciences, Quchan, Iran.
3- Student Research Committee, Quchan School of Nursing, Mashhad University of Medical Sciences, Quchan, Iran.
4- Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
5- Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Abstract: (763 Views)
Background: COVID-19 is the latest and most important global health crisis, which challenged even the most advanced healthcare systems in the world. Effective vaccination is the only solution to prevent infection and reduce the disease severity and mortality rate. The present study aimed to
determine the clinical and laboratory characteristics of hospitalized patients with COVID-19 after vaccination in Quchan County, Iran.
Methods: This is an observational analytical study with a cross-sectional scheme. The study population includes the one-year data of COVID-19 patients admitted to Musa Ibn Jafar Hospital in Quchan, Iran from March 2021 until March 2022. The data were divided into two groups vaccinated (n=123) and un-vaccinated (n=123). Three post-vaccination time windows of “no immunity”, “partial immunity”, and “full immunity” were defined to determine the length of hospitalization and death rate due to COVID-19 based on the type of vaccine. The data were collected from patient’s medical files recorded in the archive system of the hospital, the SIB system, or by calling patients or their families.
Results: The mean age of vaccinated patients was higher than that of un-vaccinated patients (P<0.001). Chest pain, muscle pain, and vomiting were significantly less common in vaccinated patients (P<0.05, P<0.01, P<0.05, corresponigly), while shivering was more common (P<0.001). The serum levels of C-reactive protein (CRP) were significantly higher in vaccinated patients (P<0.01), while the white blood cell (WBC) count was lower (P<0.05). Mortality rate (P<0.01) and the length of hospitalization (P<0.001) were significantly higher in un-vaccinated patients. Sinopharm (73.98%) and AstraZeneca
(17.7%) were the most administered vaccines. All death cases occurred in the full immunity time window (two weeks after receiving the second dose of vaccine).
Conclusion: Vaccination can reduce the length of hospitalization and mortality rate in COVID-19 patients. Therefore, further vaccination coverage is necessary to reduce the severity of disease, length of hospitalization, and mortality rate in these patients.-
determine the clinical and laboratory characteristics of hospitalized patients with COVID-19 after vaccination in Quchan County, Iran.
Methods: This is an observational analytical study with a cross-sectional scheme. The study population includes the one-year data of COVID-19 patients admitted to Musa Ibn Jafar Hospital in Quchan, Iran from March 2021 until March 2022. The data were divided into two groups vaccinated (n=123) and un-vaccinated (n=123). Three post-vaccination time windows of “no immunity”, “partial immunity”, and “full immunity” were defined to determine the length of hospitalization and death rate due to COVID-19 based on the type of vaccine. The data were collected from patient’s medical files recorded in the archive system of the hospital, the SIB system, or by calling patients or their families.
Results: The mean age of vaccinated patients was higher than that of un-vaccinated patients (P<0.001). Chest pain, muscle pain, and vomiting were significantly less common in vaccinated patients (P<0.05, P<0.01, P<0.05, corresponigly), while shivering was more common (P<0.001). The serum levels of C-reactive protein (CRP) were significantly higher in vaccinated patients (P<0.01), while the white blood cell (WBC) count was lower (P<0.05). Mortality rate (P<0.01) and the length of hospitalization (P<0.001) were significantly higher in un-vaccinated patients. Sinopharm (73.98%) and AstraZeneca
(17.7%) were the most administered vaccines. All death cases occurred in the full immunity time window (two weeks after receiving the second dose of vaccine).
Conclusion: Vaccination can reduce the length of hospitalization and mortality rate in COVID-19 patients. Therefore, further vaccination coverage is necessary to reduce the severity of disease, length of hospitalization, and mortality rate in these patients.-
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