دوره 10، شماره 3 - ( 6-1401 )
جلد 10 شماره 3 صفحات 146-137 |
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Pirdel L, Pirdel M. Low Serum 25‑hydroxyvitamin D levels: Predictive Value of Hematological and Inflammatory Markers in Patients with Urinary Tract Infection. Res Mol Med (RMM) 2022; 10 (3) :137-146
URL: http://rmm.mazums.ac.ir/article-1-470-fa.html
URL: http://rmm.mazums.ac.ir/article-1-470-fa.html
Low Serum 25‑hydroxyvitamin D levels: Predictive Value of Hematological and Inflammatory Markers in Patients with Urinary Tract Infection. Research in Molecular Medicine. 1401; 10 (3) :137-146
چکیده: (1669 مشاهده)
Background: Low vitamin D has been linked to enhance inflammatory markers in various pathological conditions. We aimed to evaluate the urinary tract infection (UTI)-associated hematological and inflammatory markers mediated by low serum levels of 25-hydroxyvitamin D [25(OH)D].
Methods: Vitamin D level, hematological indices (Neutrophil-to-lymphocyte ratio [NLR], Monocyte-to-lymphocyte ratio [MLR], Neutrophil-to-monocyte ratio [NMR], Platelet-to-lymphocyte ratio [PLR], and Mean platelet volume [MPV]), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), interleukin-6, and tumor necrosis factor-a were evaluated in 115 UTI patients and 57 controls.
Results: The findings showed an inverse association between elevated hematological (NLR, MLR, and MPV) and serum markers of inflammation (CRP, IL-6, and TNF-a) with serum 25(OH)D levels in UTI patients. Among the several markers evaluated, the MLR had the ability to suggest the associated inflammation with low serum levels of 25(OH)D.
Conclusion: The involvement of vitamin D deficiency might be characterized by an increase in the inflammatory markers in the patients which have an ability to establish the relationship between vitamin D deficiency and UTI; however, further investigations are needed to validate this finding.
Methods: Vitamin D level, hematological indices (Neutrophil-to-lymphocyte ratio [NLR], Monocyte-to-lymphocyte ratio [MLR], Neutrophil-to-monocyte ratio [NMR], Platelet-to-lymphocyte ratio [PLR], and Mean platelet volume [MPV]), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), interleukin-6, and tumor necrosis factor-a were evaluated in 115 UTI patients and 57 controls.
Results: The findings showed an inverse association between elevated hematological (NLR, MLR, and MPV) and serum markers of inflammation (CRP, IL-6, and TNF-a) with serum 25(OH)D levels in UTI patients. Among the several markers evaluated, the MLR had the ability to suggest the associated inflammation with low serum levels of 25(OH)D.
Conclusion: The involvement of vitamin D deficiency might be characterized by an increase in the inflammatory markers in the patients which have an ability to establish the relationship between vitamin D deficiency and UTI; however, further investigations are needed to validate this finding.
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