Recently, the market demand for biopharmaceuticals and nutraceuticals has increased. Consequently, high-volume production strategies have also drawn a lot of attention. The invention and development of recombinant DNA technology, using various hosts from bacteria to mammalian cells, have led to the industrial-scale manufacture of many valuable pharmaceutical products. Among the hosts, yeasts have a special place due to their numerous benefits. The present study deals with commercial yeast-derived biopharmaceuticals and laboratory-scale yeast-extracted nutraceuticals. It represents the biotechnological potential of yeasts to meet the market's needs in this area. Besides, considering the COVID-19 pandemic, the applications of yeast hosts for the clinical management of this disease have been briefly discussed.