دوره 6، شماره 4 - ( 8-1397 )                   جلد 6 شماره 4 صفحات 20-27 | برگشت به فهرست نسخه ها

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Fotoohi M, Hadi N, Namazi F. Effect of Foretinib on Matrix Metalloproteinase-2 (MMP2) Expression in Glioblastoma. Res Mol Med (RMM). 2018; 6 (4) :20-27
URL: http://rmm.mazums.ac.ir/article-1-301-fa.html
Effect of Foretinib on Matrix Metalloproteinase-2 (MMP2) Expression in Glioblastoma. Research in Molecular Medicine. 1397; 6 (4) :20-27

URL: http://rmm.mazums.ac.ir/article-1-301-fa.html


چکیده:   (688 مشاهده)
Background: The most malignant form of infiltrating astrocytoma, glioblastoma multiforme (GBM), is one of the most aggressive human cancers. Foretinib diminished GBM cell invasion by downregulating the expression of matrix metalloproteinase 2 (MMP2). The study aimed to examine the anti-tumor activity of foretinib and to test its effect on MMP2 expression in T98 cells.
Materials and methods: T98 cells were used as an experimental model of glioblastoma. The effect of foretinib on the expression of MMP2 was evaluated using quantitative real-time polymerase chain reaction. Thereafter, the effect of foretinib on the enzyme levels of MMP was examined by zymography. Statistical analyses were performed with GraphPad Prism software.
Results: A reduction in the expression of MMP2 was observed with an increase in the concentration of foretinib.
Conclusion: Foretinib treatment leads to downregulation of MMP-2 and has a positive effect on T98 cells. We believe that foretinib can be subjected to further clinical investigation to develop a treatment for GBM.
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نوع مطالعه: پژوهشي | موضوع مقاله: ژنتیک
دریافت: ۱۳۹۸/۲/۱

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