Mendeley  

Zotero  

Alqasi A, Moghimian-Boroujeni B, Javan M R, Amrovani M, Rezaeeyan H. Comparing Neutrophil-to-lymphocyte Ratio, Platelet-to-lymphocyte Ratio, and Hemoglobin-to-platelet Ratio Between Patients With Immune Thrombocytopenia and Healthy Controls: A Retrospective Study. Res Mol Med (RMM) 2025; 13 (3) :157-164
URL: http://rmm.mazums.ac.ir/article-1-591-fa.html

Background: Immune thrombocytopenia (ITP), formerly known as idiopathic thrombocytopenic purpura, is a common hematologic disorder that affects a wide range of people but is more prevalent in children and older people. Evaluation and measurement of inflammatory markers in patients with ITP are costly and time-consuming. Considering the importance of inflammation in ITP, the reduction of blood cells, and the occurrence of thrombocytopenia and anemia, the use of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and hemoglobin-to-platelet ratio (HPR) indices can be effective in ITP management due to their relevance to clinical symptoms, low cost, and availability. Therefore, we investigated these indices in this study.
Materials and Methods: This is a retrospective, descriptive, and epidemiological study conducted at Ahvaz Jundishapur University of Medical Sciences, Baqaei Hospital, Ahvaz City, Iran, in 2020 and 2021. In this study, 250 ITP patients comprised the case group, and 70 healthy individuals comprised the control group.
Results: The results showed that the mean PLR was lower in patients (1.29±2.24) than in controls (69.88±33.01), while the mean NLR (2.146±2.16 vs 0.966±0.919) and HPR (0.752±0.707 vs 0.049±0.017) in patients were significantly higher than in healthy individuals (P=0.0001). On the other hand, there was no significant difference between the mean corpuscular volume (MCV) (P=0.584) and white blood cell (WBC) (P=0.943) indices between the two groups. To evaluate the diagnostic value of PLR, NLR, and HPR indices, receiver operating characteristic (ROC) curves were used, and area under the curve (AUC) values were calculated. The AUC for NLR was about 71%, while for PLR and HPR it was 100% and 98%, respectively. 
Conclusion: In general, PLR, NLR, and HPR indices have diagnostic and prognostic value in the management of ITP.