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Mahmoodi E, Hedayatizadeh-Omran A, Moosazadeh M, Alizadeh-Navaei R, Mohammadi T, Kashi Z. Trend in Thyroid Cancer Incidence in Northern Iran: A Population-based Study (2016–2020). Res Mol Med (RMM) 2024; 12 (4)
URL: http://rmm.mazums.ac.ir/article-1-587-fa.html

Background: The incidence of thyroid cancer (TC) is increasing globally. This study examined the incidence of TC in Mazandaran Province, Northern Iran, from 2016 to 2020.
Methods: We conducted a cross-sectional study using data from the Mazandaran cancer registry. Age-standardized incidence rates (ASIRs) and the average annual percentage change (AAPC) with 95% confidence intervals (CI) were calculated using the Joinpoint Regression Program software, version 4.9.0.0.
Results: The number of cases rose by 90.9%, increasing from 253 in 2016 to 483 in 2020. The ASIR increased from 6.43 to 11.14 per 100,000. While the overall trend was not statistically significant (AAPC=14.5%, P=0.08), a significant increase was observed in males (AAPC=19.8%, P<0.05). The incidence rate in women was approximately five times that of men (15.14 vs 3.06 per 100,000, P<0.001) and was more common in urban areas.. Most new cases (over 80%) occurred in the 25–59 age group.
Conclusion: TC incidence has risen substantially in Mazandaran Province, particularly among women and urban residents. These findings highlight the need for further investigation into underlying causes and preventive measures.