Research in Molecular Medicine

en Serum Level of Sex Hormones in Women With Colon Cancer in Northern Iran هماتولوژی و آنکولوژی Hematology & Oncology پژوهشي Research <div style="text-align: justify;">Background: The incidence of colorectal cancer (CRC) is lower among women than among men in all age groups, and higher estradiol exposure in women is thought to have a protective role. This study aimed to investigate the relationship between sex hormones and the risk of CRC in women. Methods: This study explored the relationship between the risk of CRC and estradiol, testosterone, progesterone, and sex hormone-binding globulin (SHBG) concentrations in non-current users of exogenous hormones. Multivariate conditional logistic regression models were applied to calculate odds ratios and 95% confidence intervals to estimate the association between circulating sex hormone levels and CRC. Results: Median levels of estradiol and SHBG were found to be significantly high in women with CRC but circulating levels of progesterone in patients were significantly lower than those in controls. No correlation was observed between estradiol, testosterone, progesterone, and SHBG and CRC after adjusting for age and menopausal status. Conclusion: Based on current findings, relationships between CRC risk and the levels of progesterone, testosterone, and SHBG seem unlikely. Future studies may be required to elucidate the association between estradiol levels and CRC risk in women using greater sample sizes and well-defined boundaries.</div> Colorectal cancer, Estrogen, Progesterone 0 0 http://rmm.mazums.ac.ir/browse.php?a_code=A-10-777-3&slc_lang=en&sid=1 Ramin Shekarriz raminshf@gmail.com 100319475328460013776 100319475328460013776 No Gastrointestinal Cancer Research Center, Non-Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran Akbar Hedayatizadeh-Omran akbar_hedayati@yahoo.com 100319475328460013777 100319475328460013777 Yes Gastrointestinal Cancer Research Center, Non-Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran Niloofar Sadeghi niloofar.sadeghi9069@gmail.com 100319475328460013778 100319475328460013778 No Gastrointestinal Cancer Research Center, Non-Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran Reza Alizadeh-Navaei reza-nava@yahoo.com 100319475328460013779 100319475328460013779 No Gastrointestinal Cancer Research Center, Non-Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran Omolbanin Amjadi prs.amjadi0o0@gmail.com 100319475328460013780 100319475328460013780 No Gastrointestinal Cancer Research Center, Non-Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran Adele Bahar doctor_bahar2000@yahoo.com 100319475328460013781 100319475328460013781 No Diabetes research center, Mazandaran university of Medical Sciences, Sari, Iran