Research in Molecular Medicine
Research in Molecular Medicine
Res Mol Med (RMM)
Medical Sciences
http://rmm.mazums.ac.ir
1
admin
2322-1348
2322-133X
10.29252/rmm
en
jalali
1398
5
1
gregorian
2019
8
1
7
3
online
1
fulltext
en
Effect of Platelet-rich Plasma and Mesenchymal Stem Cells as Two Biological Alternatives in Rotator Cuff Injury Treatment: A Mini-review
بیوتکنولوژی
Biotechnology
review
review
<div style="text-align: justify;">The rotator cuff injury is caused by significant damage by trauma or other factors and currently recognized as a prevalent orthopedic problem. Many clinical procedures have been proposed to reduce the complication of rotator cuff injury with varying degrees of success. A literature search was conducted of PubMed and ISI Web of Knowledge using relevant keywords as well as government website for clinical trial. Platelet-rich plasma (PRP) is one of the most effective strategies for the symptomatic treatment of rotator cuff injury. Many parameters can influence the result of PRP, including intensity of rotator cuff injury, patient’s age, PRP producing strategy, and frequency and timing of PRP injections. However, some evidence supports the beneficial effect of PRP in relieving pain and restoring function, along with its minimal adverse effects, compared with using corticosteroids and other nonsurgical methods. Besides platelet-rich plasma, mesenchymal stem cells (MSCs) are another alternative that can be used to treat rotator cuff injuries. Because enough large clinical trials cannot be applied, using these biological cells have their challenges similar to PRP. In conclusion, further research is necessary to understand the potential application of both methods as safe and effective therapeutic options for rotator cuff injuries.</div>
Platelet-rich plasma, Mesenchymal stem cells, Rotator cuff injury
1
8
http://rmm.mazums.ac.ir/browse.php?a_code=A-10-1069-2&slc_lang=en&sid=1
Mohsen
Sheykhhasan
mohsen.sh2009@gmail.com
10031947532846008536
10031947532846008536
Yes
Department of Mesenchymal Stem Cell, the Academic Center for Education, Culture and Research, Qom, Iran.
Hamed
Manoochehri
hamedmanoochehry@yahoo.com
10031947532846008537
10031947532846008537
No
Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
Pouria
Samadi
psequencer@gmail.com
10031947532846008538
10031947532846008538
No
Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
Reza
Fotouhi-Ardakani
10031947532846008539
10031947532846008539
No
Cellular and Molecular Research Center, Qom University of Medical Sciences, Qom, Iran.
Naser
Kalhor
naserkalhor@gmail.com
10031947532846008540
10031947532846008540
No
Department of Mesenchymal Stem Cell, the Academic Center for Education, Culture and Research, Qom, Iran.