Research in Molecular Medicine
Research in Molecular Medicine
Res Mol Med (RMM)
Medical Sciences
http://rmm.mazums.ac.ir
1
admin
2322-1348
2322-133X
10.29252/rmm
en
jalali
1398
2
1
gregorian
2019
5
1
7
2
online
1
fulltext
en
Bovine Leukaemia Virus Tax Antigen Identification in Human Lymphoma Tissue: Possibility of onco-protein Gene Ttransmission
ميکروبيولوژي
Microbiology
پژوهشي
Research
<div style="text-align: justify;"><strong>Background:</strong> Bovine leukaemia virus (BLV) is the cause of enzootic bovine leukaemia which belongs to retroviruses including Human T-cell leukaemia virus and simian T-lymphotropic virus. Due to this familiarity, the possibility of virus (BLV) transfer from animal production to humans may exist.<br>
<strong>Materials and methods: </strong>In the present study, formalin-fixed, paraffin-embedded and fresh human lymphomas tissues were used for detecting the BLV Tax genome and BLV Tax expression using nested-PCR and RT-nested-PCR.<br>
<strong>Results: </strong>Nested-PCR evaluation showed that 9 of 41 samples contained Tax region of BLV genome, of which eight samples belonged to high grade diffuse large cell lymphoma (B-cell type). Also, the results of RT-nested-PCR showed the BLV Tax expression in 2 of 5 high grade diffuse large cell lymphoma (B-cell type) samples.</div>
<strong>Conclusion: </strong>These findings explain the possible relation between BLV infection and the occurrence of some types of human lymphomas for the first time.
BLV, lymphoma, nested PCR, RT-nested-PCR, Tax.
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http://rmm.mazums.ac.ir/browse.php?a_code=A-10-1102-1&slc_lang=en&sid=1
Camellia
Taghadosi
camellia.taghadosi@gmail.com
10031947532846008574
10031947532846008574
No
Graduated student, Faculty of Veterinary Medicine, Shahrekord university, Shahrekord, Iran.
Gholamali
Kojouri
drgholam_alikojouri@yahoo.com
10031947532846008575
10031947532846008575
Yes
Professor, Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahrekord university
Alimohammad
Ahadi
ahadi52@gmail.com
10031947532846008576
10031947532846008576
No
Assistant Professor, Department of Genetic, Faculty of Basic Sciences, Shahrekord University, Shahrekord, Iran.
Mohammad
Hashemi Bahremani
mbahremani@yahoo.Com
10031947532846008577
10031947532846008577
No
Associate Professor, Laboratory of Pathology, Emam Hosein Hospital, Tehran, Iran.
Abdolnabi
Kojouri
10031947532846008578
10031947532846008578
No
Faculty of Medicine, International Campus of Shahid Sadoughi Medical University, Yazd, Iran