Research in Molecular Medicine
Research in Molecular Medicine
Res Mol Med (RMM)
Medical Sciences
http://rmm.mazums.ac.ir
1
admin
2322-1348
2322-133X
10.29252/rmm
en
jalali
1397
5
1
gregorian
2018
8
1
6
3
online
1
fulltext
en
An Overview of the Epigenetic Modifications of Gene Expression in Tumorigenesis
ژنتیک
Genetic
review
review
<div style="text-align: justify;">The five leading causes of cancer-related deaths are lung (1,760,000 deaths), colorectal (862,000 deaths), stomach (783,000 deaths), liver (782,000 deaths), and breast (627,000 deaths) cancers. Epigenetic changes can alter chromatin compaction, leading to the regulation of geneexpression without changing the primary DNA sequence.Epigenetic mechanisms are normally involved incellular processes such asgenomic stability, chromosome X inactivation, and embryonic development and differentiation. Similar to other types of chromatin modifications, DNA methylation has been verifiedto affect the expression of various genes. Any impairment in these mechanisms alters the regulation of gene expression and can contribute to malignant cell transformation. Over the past few years, extensive innovations within the field of epigenetics have encouraged its application as a major strategy for the treatment of important diseases such as cancer.</div>
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Cancer, epigenetic, methylation, gene expression
1
19
http://rmm.mazums.ac.ir/browse.php?a_code=A-10-26-40&slc_lang=en&sid=1
Leili
Sadeghi-Amiri
alibar647@yahoo.com
10031947532846007728
10031947532846007728
Yes
Department of Basic Sciences, Sari Agriculture Scienceand Natural Resources University, Sari, Iran
Ali
Barzegar
alibar647@yahoo.com
10031947532846007729
10031947532846007729
No
Department of Basic Sciences, Sari Agriculture Scienceand Natural Resources University, Sari, Iran
Alireza
Rafiei
Rafiei1710@gmail.com
10031947532846007730
10031947532846007730
No
Department of Immunology, Molecular and Cell Biology Research Center, Mazandaran University of Medical Sciences, Sari, Iran
Omolbanin
Amjadi
prs.amjadi0o0@gmail.com
10031947532846007731
10031947532846007731
No
Department of Molecular Medicine, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran