Research in Molecular Medicine
Research in Molecular Medicine
Res Mol Med (RMM)
Medical Sciences
http://rmm.mazums.ac.ir
1
admin
2322-1348
2322-133X
10.29252/rmm
en
jalali
1393
11
1
gregorian
2015
2
1
3
1
online
1
fulltext
en
Identification and prioritization genes related to Hypercholesterolemia QTLs using gene ontology and protein interaction networks
ژنتیک
Genetic
پژوهشي
Research
<p>Gene identification represents the first step to a better understanding of the physiological role of the underlying protein and disease pathways, which in turn serves as a starting point for developing therapeutic interventions. Familial hypercholesterolemia is a hereditary metabolic disorder characterized by high low-density lipoprotein cholesterol levels. Hypercholesterolemia is a quantitative trait that is controlled by interactions among several quantitative trait loci. Many biological data is presented in the context of biological networks and evaluation of biological networks is considered as the essential key to understanding complex biological systems. In this research, we used combination of information about quantitative trait loci of hypercholesterolemia with information of gene ontology and protein–protein interaction network for identification of genes associated with hypercholesterolemia. For this disease, we introduced 16 new genes which were in quantitative trait loci regions and were associated with the hypercholesterolemia disease in terms of gene ontology characteristics.</p>
Complex disease, Disease gene prediction, Familial hypercholesterolemia, Protein interaction network, Quantitative trait loci
18
23
http://rmm.mazums.ac.ir/browse.php?a_code=A-10-698-1&slc_lang=en&sid=1
Ali
Kazemipour
ali.kazemi110@gmail.com
10031947532846005873
10031947532846005873
No
Institute of Biochemistry and Biophysics, University of Tehran
Bahram
Goliaei
goliaei@ibb.ut.ac.ir
10031947532846005874
10031947532846005874
Yes
Institute of Biochemistry and Biophysics, University of Tehran
Hamid
Pezeshk
hamid.pezeshk@gmail.com
10031947532846005875
10031947532846005875
No
University of Tehran
Behjat
Kalantari khandani
dkalantarikhandani@gmail.com
10031947532846005876
10031947532846005876
No
Kerman University of Medical Sciences