TY - JOUR JF - Res-Mol-Med JO - Res Mol Med (RMM) VL - 4 IS - 3 PY - 2016 Y1 - 2016/8/01 TI - Evaluation of Long Stress-Induced Non-coding Transcripts 5 Polymorphism in Iranian Patients with Bladder Cancer TT - N2 - Background: Bladder cancer (BC) is the most commonly diagnosed genitourinary cancer in Iran, presented in both men and women. BC is a multifactorial trait resulting from the complex interaction between several genes and environmental factors. Long stress-induced non-coding transcript 5 (LSINCT5), a member of the long non-coding RNAs, is abundantly expressed in high proliferative cells, as well as the cells vulnerable to cellular stress in response to chemical carcinogens. This case-control study aimed to determine any association between LSINCT5 rs2962586 polymorphism and bladder cancer. Materials and Methods: A group of 150 patients with BC were compared with 143 subjects as a control group. Genotyping of the rs2962586 polymorphism was done using tetra- primer amplification refractory mutation system-polymerase chain reaction (T-ARMS PCR) method. Results: Genotype and allele distribution were not significantly different between the case and control groups. Smoking was found to be the confounding risk factor for bladder cancer. Conclusion: Considering the result of our analyses, it seems that LSINCT5 could not affect individual susceptibility to BC among Iranian patients, however, it can be considered as a disease predictor among smokers. SP - 17 EP - 21 AU - Nazari, Mahla AU - Nasiri, Mahboobeh AU - Ghaderi, Abbas AD - Department of Biology, Islamic Azad University, Arsanjan Branch, Arsanjan, Iran KW - Bladder cancer KW - Long stress induced non-coding transcript 5 KW - Polymorphism UR - http://rmm.mazums.ac.ir/article-1-198-en.html DO - 10.18869/acadpub.rmm.4.3.17 ER -